Yin Loon Lee
@YLLee_CellBio
Cell biologist from 🇸🇬 @astar_research, co-founder at Nuevocor, postdoc @LabBurke, PhD @StearnsLab. Nuclear mechanotransduction, #microtubules, #RareDisease.
My first paper as a co-corresponding author has been accepted @hmg_journal. A long-running team effort with co-first authors Ei Leen and Thet, @cadotbru and other authors, my thanks to @LabBurke and Colin Stewart for letting me drive this. academic.oup.com/hmg/advance-ar…?
Check out our lab's latest review by @MFarisHazwan @MBIsg @BME_NUS in Current Opinion in Cell Biology @sciencedirect 🔗sciencedirect.com/science/articl… We teamed up w/Brian Aguado @ucsdbe to highlight region- & sex-specificity of #ECM signaling in the aging heart!🫀 Hope you enjoy!
What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: biorxiv.org/content/10.110……
Interested in a #postdoc on cardiac #mechanobiology? Our lab has a fully funded position via our recently awarded @HFSP grant to study the biophysical processes that build insect hearts🪲🪰🫀 Come join us @MBIsg for some cool evo-devo-mechanobio work! 👇 mbi.nus.edu.sg/jobs/seeking-p…
I am looking to hire a postdoctoral fellow to work on a collaborative project at the Mechanobiology Institute with the inimitable Sasha Bershadsky, focusing on interactions between the nucleus and the cell-ECM junctions in directed cell migration. mbi.nus.edu.sg/jobs/seeking-p…
Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the @ConfinementLab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!
Our heartfelt condolences to Linda and all affected by this devastating news. Prof Michael Sheetz was an inspirational Founding Director of MBI and we would not be here today without his foresight and leadership. We hope to continue his legacy in mechanobiology for years to come.
My heart is broken as I announce the passing of my beloved husband, science partner and friend, Michael Sheetz. A remarkable scientist we packed 40 years of living into 20. Rejuvenation of senescent cells and mice in Press in Aging Cell; his last words were this was his best work
The @ConfinementLab's latest paper is out in @PNASNews! Fantastic work by @LY_Sci to build a tool to rapidly and accurately measure nuclear volume and surface area in #confinement. Thread below: pnas.org/doi/10.1073/pn…
Ok looks like we’re reaching critical mass on the other place! I won’t delete this account but I’ll stop actively posting - see you over there 💙
👇SAVE the date 👇As the chair of the upcoming European meeting on Intermediate Filaments, I am happy to announce its launching. RT & more details to come. Thx organizing team with @BonneGisele @etiennemannevil A.Bertrand O.Agbulut #cytoskeleton @ConnectingIFs
This may be obvious to some but I'm now convinced: fierce competition for grants and papers is leading to low societal ROI (return on investment). Why, when competition should mean only the best-formulated and executed work is accepted for funding and high-profile publication?
We’re thrilled to see our artistic rendition of the keratin intermediate filament cytoskeleton highlighted on the cover of @Dev_Cell along with our paper! cell.com/developmental-…
Shifts in keratin isoform expression activate motility signals during wound healing cell.com/developmental-…
🚨 Super psyched this story is finally out! Herculean effort and 3rd chef d’oeuvre in @NatCellBio by @patriziaromani in just 5y, where we describe #mitochondrial #mechanotransduction. nature.com/articles/s4155… Megathread with bonuses ⬇︎⬇︎⬇︎
Congrats to Ambros and Ruvkun! Read the original papers, which appeared together in 1993: pubmed.ncbi.nlm.nih.gov/8252621/ pubmed.ncbi.nlm.nih.gov/8252622/ Back then, the finding that small RNAs - not protein - produced at one locus could control protein expression from another was big news!
Happy to share (time-limited) free access to our latest work @Dev_Cell by Fabian Zimmermann @LudersLab @IRBBarcelona and @sernarina @CNIOStopCancer @LlorcaLab: authors.elsevier.com/a/1jpyq_Yv6zvB… By reconstitution and #cryoEM we show how the #microtubule nucleator #gTuRC gets activated 🧵👇
Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…
The founder and former CEO of Vertex Pharmaceuticals, Joshua Boger, was once asked: "What does it take to be a good leader in a pharmaceutical company?" Boger said, "Pharmaceutical discovery and development is the most complicated activity that humans do. Going to Mars is easy,…
We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/
Excited to announce…..it’s finally arrived (!!) nature.com/articles/s4155… A big thank-you to my team (particularly @robertr33), co authors & #FutureFellowship funding from @arc_gov_au Importantly- a big shoutout to @drDJVDavid @NatureCellBio for their support. 👇tweetorial 👇…
Buckle in, it is #microtubule cell migration story time! We reveal a new role for microtubules as cellular sensors which detect and respond to compressive forces, enabling movement and ensuring survival in mechanically demanding environments; just like this little guy squeezing…