Juan Villar-Vesga

Check out our most recent work resolving a longstanding controversy: which phagocyte subset drives oxidative damage in neuroinflammation? Thank you for the support and the mentoring @SarahMundt5. Thanks to Mundtlab, @BecherLab and all coauthors! Link: biorxiv.org/content/10.110…

Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes | Molecular Psychiatry nature.com/articles/s4138…

🧵1/ Excited to share my first publication from the @ColonnaLab in @NatImmunol! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…

🚨 Fellowship Alert! 🚨 The Sergio Lombroso Fund is offering postdoc fellowships for 🇮🇹 Italian researchers in cancer research at @WeizmannScience 🧬 Join a world-class cancer immunotherapy program 📅 Deadline: July 8 👉 Apply now: erez.weizmann.ac.il/pls/htmldb/f?p… #CancerResearch #Italy

These advances show that science is reproducible. Debating “perfect reproducibility” in biology is a distraction. Living systems are complex and context-dependent. What matters is convergence across models not identical results. Let’s not waste time discussing the wrong problem.

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain: cell.com/immunity/fullt… @ImmunityCP

We are excited to share our new study @Cancer_Cell identifying Zeb2 as a master genetic switch controlling the tumor-associated macrophage (TAM) program. Led by @FadiSheban, @TgSanPhan, @CuriousKX & @FlorianIngelfi1. (1/20) cell.com/cancer-cell/fu…

Are you an immunologist interested in spatially-resolved single cell technologies and generative modeling but dont know where to start? Check out our @EurJImmunol review with Avital, Hosna, Robert Zeiser, @IdoAmitLab, @YosefLab & @WertheimerT onlinelibrary.wiley.com/doi/10.1002/ej…

Perspective from Michal Schwartz and colleagues: Monocyte-derived #macrophages act as reinforcements when #microglia fall short in #Alzheimer’s disease nature.com/articles/s4159…

Beyond misalignment of science in the news and in schools @ScienceMagazine @ErduranSibel science.org/doi/10.1126/sc…

Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells, say Colin Sparano (@csparano93), Darío Solís-Sayago (@SolisSayago), Sonia Tugues @TuguesLab and colleagues @UZH_en: hubs.la/Q0302VDw0 #InnateImmunity #LymphocyteBiology

Check out the most recent beautiful work of @csparano93, @SolisSayago and the @TuguesLab!

Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…

.@AlessandraGurt1, @CrepazDaniel & @lab_arnold discuss recent progress in our understanding of #eosinophil activities within tissues, particularly the gastrointestinal tract. hubs.la/Q02YQ6Hs0 📚 Part of our Immunity Review Series: hubs.la/Q02YQ6fz0 #Immunology

Another @preprintclub Journal Club by Zi Yan Chen & @nkg2d1 @ImmunologyUofT discusses @biorxivpreprint by @VillarVesga et al. @BecherLab @SarahMundt5 showing that monocyte-derived cells in CNS produce mitochondrial ROS to promote neuroinflammation bit.ly/495E7HP

Pathogenic role of mitochondrial ROS in neuroinflammation with monocyte-derived cells rather than microglia as the primary driver of ROS-mediated neuropathology @VillarVesga @SarahMundt5 papers.ssrn.com/sol3/papers.cf…

Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. @jonykipnis nature.com/articles/s4158…

Amazing work understanding tolerance inducing peptides in the CNS. Congrats @mitchkim_mw @jonykipnis @kipnislab

Macrophages do a whole lot more. They are a major subunit of basically all tissues. They protect the brain from damage, regulate thermogenesis in adipose tissue, and are electrically coupled to cardiomyocytes in the heart. They are the immune system's ultimate Swiss Army knife!

Very honored to have been featured at Preprint Club !!

Hub#1 is back TODAY 🥳 we will start with Arthur Mortha @nkg2d1 from @ImmunologyUofT , who will present a #preprint by @BecherLab and @SarahMundt5 labs about the role of monocyte-derived cells in oxidative tissue damage in neuroinflammation 🤯💥🩹 👇 biorxiv.org/content/10.110…