Cardiac Research
@UKheartresearch
Translational cardiovascular research group @KingsCollegeLon and @GSTTnhs. From hypothesis-led in vivo studies to multicentre clinical trials. @Kings_BHFCentre
What better way to launch our @YouTube channel youtube.com/@ukheartresear… than with a brilliant summary of the SERIAL trial by @mattlkw! youtu.be/xqCdxL-pUiQ?fe…
This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynamic benefits of #PCI. Post-PCI physiology should be routinely performed in diffuse & serial disease. jacc.org/doi/10.1016/j.… @divaka_perera @mattlkw #JACCINT
🔑 We recommend using adenosine, dobutamine & ACh for full MB phenotyping in the cath lab 🔑 bit.ly/3TnnY9y @JEscaned @VTaqMD @ColletCarlos @iamritu @VijayKunadian @wfearonmd @habib_samady @JanetWeiMD @samitshahmd @Michel_CorbanMD @rajivxgulati @DrMarthaGulati
🚨@REVIVED_BCIS2 scar analysis🫀 ➡️Scar volume & pattern highly associated with death and arrhythmia ➡️Scar assessment should be routine, particularly in those at borderline risk Out now @JACCJournals CVI🔗 jacc.org/doi/10.1016/j.… 📺Watch our summary👇 youtu.be/-eMrPRPToM0
Great work by the SERIAL Trial investigators 👏 First RCT of FFR vs iFR in Serial Disease 🎯 FFR & iFR systematically overestimate the result of PCI in serial and diffuse coronary disease jacc.org/doi/10.1016/j.… @BCIS_uk @mmamas1973 @ncurzen @aayshacader @DFCapodanno @drjohnm
Outstanding work! 👏 This is the first randomized study comparing resting and hyperemic pullbacks. 🔑 Key finding: Both resting (iFR) and hyperemic (FFR) pullbacks are equally influenced by lesion cross-talk. ✅ This settles a long-standing debate in the physiology field.
@divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD 📺 youtu.be/M3CGzreHwlI 🔗jacc.org/doi/10.1016/j.… @mattlkw @UKHeartResearch @JACCJournals #JACCINT #ACCFIT
A clear and concise lay summary by @TheBHF on the impact of the LMCA Physiology study👏 🔗Manuscript: ahajournals.org/doi/10.1161/CI… - @CircIntv @SVRaoMD 🔗Editorial: ahajournals.org/doi/10.1161/CI… - @wfearonmd 🔗BHF 📰: bhf.org.uk/what-we-do/new… @kingsmedicine @kingscardio @Kings_BHFCentre
Everything you wanted to know about INOCA in 2 days! Well worth registering asap for #INOCA2025, a @TheBHF - @NIHRresearch CV partnership meeting. Stellar international faculty, guideline updates, how to sessions, debates, breaking research, discussion, live cases and more!
Registration is OPEN for #INOCA2025! 🗓️ 25–26 Sept | 📍 London Join @divaka_perera and @achir76, for two days of cutting-edge insights into Coronary Microvascular Dysfunction. ✅ Live cases ✅ Patient stories ✅ Tech & trials ✅ Real-world clinical tools Register here:…
Amazing to complete #L2B2025 with so many of different abilities ages and attire, whether they or loved ones have been affected, or they devote their time to fight heart disease, united to help @TheBHF do the fantastic work they do! You can still donate- justgiving.com/team/cardiaccy…
And just like that, the 2025 #LondontoBrighton is complete! 🎉 A huge congrats to each and every #TeamBHF rider out there today and thank you for your amazing support. We hope you’re proud of what you’ve achieved - we’re certainly proud of you. ❤️
Our IPD analysis of @REVIVED_BCIS2 and STICH is out in print today! Did PCI fail to match CABG, or did medical therapy move the goalposts? Exciting implications for @BCIS4Trial, which will complete the circle. doi.org/10.1093/eurhea…
Exciting that @CHIP_BCIS3 is now in the follow-up phase! The question of elective perc LV unloading to improve patient outcomes in high-risk PCI remains as pertinent now as when this RCT started in 2021. doi.org/10.1161/CIRCIN… Whatever the result, it’ll be worth the wait⏳
📆Are you attending our next Investigators' Meeting on Thurs 12th June 2:30-3:30pm? ⏲️Don't miss out on key updates including plans for the remaining follow-up and insightful short talks from collaborators across the UK. 📨RSVP now at [email protected]
I think they should - especially for microcirculation? … which has big implications for our current clinical protocols?
📰tctmd.com/news/pressure-… 🔗ahajournals.org/doi/full/10.11… ⁉️ Should diagnostic thresholds for FFR, iFR, CFR be specific to each vessel. @TCTMD @TCTMD_Caitlin @CircIntv @SVRaoMD @wfearonmd @mmamas1973 @GreggWStone @drjohnm @ncurzen @rallamee @ShrillaB @gbiondizoccai @JEscaned
📰tctmd.com/news/pressure-… 🔗ahajournals.org/doi/full/10.11… ⁉️ Should diagnostic thresholds for FFR, iFR, CFR be specific to each vessel. @TCTMD @TCTMD_Caitlin @CircIntv @SVRaoMD @wfearonmd @mmamas1973 @GreggWStone @drjohnm @ncurzen @rallamee @ShrillaB @gbiondizoccai @JEscaned
Pressure-Based Physiological Testing Results Diverge Between LAD, LCx tctmd.com/news/pressure-… @DrOzanDemir @divaka_perera @TheBHF @kingscardio @TCTMD @TCTMD_Caitlin @CircIntv @wfearonmd
Pressure-Based Physiological Testing Results Diverge Between LAD, LCx tctmd.com/news/pressure-… @DrOzanDemir @divaka_perera @TheBHF @kingscardio @TCTMD @TCTMD_Caitlin @CircIntv @wfearonmd
@TheBHF funds more than 50% of cardiovascular research in the UK, leading to major advances in the fight against heart and circulatory disease. I will be cycling approximately 100km #L2B2025 on 15th June to raise funds for this amazing charity. justgiving.com/team/cardiaccy…
Have you seen the new publication from INOCA International Medical Advisory Board member, Professor Divaka Perera and colleagues? 😃 You can view the full article here - ahajournals.org/doi/10.1161/CI… You can learn more about INOCA here - INOCAInternational.com
Fascinating piece of research by @divaka_perera & team…. Raises questions re pressure wire assessment of left main AND whether assessment of coronary microcirculation should be multi territory on a routine basis!
Pressure-Derived Indices in Left Main Coronary Artery Disease @CircIntv ➡️ PW indices differ significantly between the LAD and LCx in isolated LMCA due to inherent differences in microvascular resistance and coronary flow. 🔗ahajournals.org/doi/10.1161/CI… @TheBHF @kingscardio
🎯MRR is independent of epicardial disease and vessel specific 🔗ahajournals.org/doi/10.1161/CI… ➡️MRR was similar in between-cohort analysis: LAD MRR values in Isolated LMCA 🟰 Normal coronary values @BernardBruyne @wfearonmd @ColletCarlos @EmanueleBarba13 @mmamas1973 @PCRonline
Are pressure-based indices vessel agnostic? Pressure derived indices in the Left Main @achir76 @drkogallagher @DrOzanDemir @k_desilva @mattlkw @divaka_perera @ukHeartResearch @theBHF #cardiotwitter #AHAJournals ahajrnls.org/3H6YdY0
Are pressure-based indices vessel agnostic? Pressure derived indices in the Left Main @achir76 @drkogallagher @DrOzanDemir @k_desilva @mattlkw @divaka_perera @ukHeartResearch @theBHF #cardiotwitter #AHAJournals ahajrnls.org/3H6YdY0
📣 This is because Microvascular Resistance Reserve is higher and minimal microvascular resistance lower in the LAD than the Circumflex ➡️ LMCA should always be assessed with PW in LAD (+ pullback) ⁉️ should diagnostic thresholds for FFR, iFR be specific to each vessel
📣 Coronary Flow Reserve is higher in the LAD than the LCx in the unobstructed coronary circulation 📣 MRR is independent of epicardial disease but different in the LAD and LCx ➡️ diagnostic thresholds for microvascular dysfunction (by CFR or MRR) are specific to each vessel