Divaka Perera
@divaka_perera
Is FFR/iFR the same in the LAD and LCx in isolated LMCA disease? We are excited to share our #disruptive findings, online @CircIntv today ahajournals.org/doi/10.1161/CI… ‼️ All pressure-based indices are LOWER in the LAD than in LCx (misclassification 21% by FFR 28% by iFR)

🔑 We recommend using adenosine, dobutamine & ACh for full MB phenotyping in the cath lab 🔑 bit.ly/3TnnY9y @JEscaned @VTaqMD @ColletCarlos @iamritu @VijayKunadian @wfearonmd @habib_samady @JanetWeiMD @samitshahmd @Michel_CorbanMD @rajivxgulati @DrMarthaGulati
➡️ Among patients with EF <30%, those with more scar have significantly worse outcomes ➡️ Even in those with slightly better EF (30-40), we can identify those at higher risk by looking at the volume and pattern of their scar
Unravelling the contributions of ischaemia and scar in arrhythmogenesis - these two papers give us the answers!⚡️🫀 Ischaemia paper 🔗 pubmed.ncbi.nlm.nih.gov/39661477/ @divaka_perera @achir76 @sohaibnazir @webmd11 @drjohnm @LambiasePier @SVRaoMD @aayshacader @DrMarthaGulati @TCTMD_Yael
🚨@REVIVED_BCIS2 scar analysis🫀 ➡️Scar volume & pattern highly associated with death and arrhythmia ➡️Scar assessment should be routine, particularly in those at borderline risk Out now @JACCJournals CVI🔗 jacc.org/doi/10.1016/j.… 📺Watch our summary👇 youtu.be/-eMrPRPToM0
🚨@REVIVED_BCIS2 scar analysis🫀 ➡️Scar volume & pattern highly associated with death and arrhythmia ➡️Scar assessment should be routine, particularly in those at borderline risk Out now @JACCJournals CVI🔗 jacc.org/doi/10.1016/j.… 📺Watch our summary👇 youtu.be/-eMrPRPToM0
Fascinating & outstanding research by @divaka_perera & team.
Great work by the SERIAL Trial investigators 👏 First RCT of FFR vs iFR in Serial Disease 🎯 FFR & iFR systematically overestimate the result of PCI in serial and diffuse coronary disease jacc.org/doi/10.1016/j.… @BCIS_uk @mmamas1973 @ncurzen @aayshacader @DFCapodanno @drjohnm
ICYMI: Registration is open for #INOCA2025, bringing together clinicians, researchers, patients and industry experts to share insights and foster collaboration💚 🗓️25-26 Sept | 📍London Institute for Healthcare Engineering 🔍An in-depth look at coronary microvascular…
@divaka_perera shares insights from the SERIAL study: 1st randomized comparison of #FFR & #iFR in serial CAD 📺 youtu.be/M3CGzreHwlI 🔗jacc.org/doi/10.1016/j.… @mattlkw @UKHeartResearch @JACCJournals #JACCINT #ACCFIT
What better way to launch our @YouTube channel youtube.com/@ukheartresear… than with a brilliant summary of the SERIAL trial by @mattlkw! youtu.be/xqCdxL-pUiQ?fe…
This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynamic benefits of #PCI. Post-PCI physiology should be routinely performed in diffuse & serial disease. jacc.org/doi/10.1016/j.… @divaka_perera @mattlkw #JACCINT
This first randomized comparison of FFR & iFR in serial #cvCAD shows that both FFR & iFR pullbacks overestimate hemodynamic benefits of #PCI. Post-PCI physiology should be routinely performed in diffuse & serial disease. jacc.org/doi/10.1016/j.… @divaka_perera @mattlkw #JACCINT
Great work @mattlkw and the SERIAL Trial group! 1️⃣ pre-PCI #pullback is essential (can change treatment strategy and target lesion) 2️⃣ BUT we tend to overestimate the effect of PCI/underestimate impact of non-target disease by FFR or iFR 3️⃣ must check post-PCI FFR+pullback
🚨FFR and iFR systematically overestimate the result of PCI in serial and diffuse coronary disease 🚨 #CoronaryPhysiology 🎲Randomised 👁️Blinded 🙋♀️Within patient comparison 🔗 Full link @JACCJournals jacc.org/doi/10.1016/j.… 📺Watch our summary below👇
Refractory angina: mechanisms and stratified treatment in obstructive and non-obstructive chronic myocardial ischaemic syndromes. Read more in EHJ. doi.org/10.1093/eurhea… @ESCardio @ESC_Journals
Everything you wanted to know about INOCA in 2 days! Well worth registering asap for #INOCA2025, a @TheBHF - @NIHRresearch CV partnership meeting. Stellar international faculty, guideline updates, how to sessions, debates, breaking research, discussion, live cases and more!
Registration is OPEN for #INOCA2025! 🗓️ 25–26 Sept | 📍 London Join @divaka_perera and @achir76, for two days of cutting-edge insights into Coronary Microvascular Dysfunction. ✅ Live cases ✅ Patient stories ✅ Tech & trials ✅ Real-world clinical tools Register here:…
Registration is OPEN for #INOCA2025! 🗓️ 25–26 Sept | 📍 London Join @divaka_perera and @achir76, for two days of cutting-edge insights into Coronary Microvascular Dysfunction. ✅ Live cases ✅ Patient stories ✅ Tech & trials ✅ Real-world clinical tools Register here:…
A brilliant couple of weeks for our excellent colleague @DrNBriceno at #WexhamCardiology @FrimleyHealth @FrimleyHC @FHFTexcel!!! Great work Natalia
Congrats to our @Kings_BHFCentre colleague Prof Divaka Perera who completed the London to Brighton Bike Ride yesterday to raise money for @TheBHF Divaka has blown past his target of £1,350, but there's still time to donate! Consider giving here: justgiving.com/team/cardiaccy…
Amazing to complete #L2B2025 with so many of different abilities ages and attire, whether they or loved ones have been affected, or they devote their time to fight heart disease, united to help @TheBHF do the fantastic work they do! You can still donate- justgiving.com/team/cardiaccy…
And just like that, the 2025 #LondontoBrighton is complete! 🎉 A huge congrats to each and every #TeamBHF rider out there today and thank you for your amazing support. We hope you’re proud of what you’ve achieved - we’re certainly proud of you. ❤️
Our IPD analysis of @REVIVED_BCIS2 and STICH is out in print today! Did PCI fail to match CABG, or did medical therapy move the goalposts? Exciting implications for @BCIS4Trial, which will complete the circle. doi.org/10.1093/eurhea…
Exciting that @CHIP_BCIS3 is now in the follow-up phase! The question of elective perc LV unloading to improve patient outcomes in high-risk PCI remains as pertinent now as when this RCT started in 2021. doi.org/10.1161/CIRCIN… Whatever the result, it’ll be worth the wait⏳
📆Are you attending our next Investigators' Meeting on Thurs 12th June 2:30-3:30pm? ⏲️Don't miss out on key updates including plans for the remaining follow-up and insightful short talks from collaborators across the UK. 📨RSVP now at [email protected]