Herbert B Schiller

Big milestone - single cell genomics of perturbations in human lung tissue. We work on scaling this approach towards `phenoscaping´ the plasticity of lung tissue states. @discovAIR_HCA @CPC_Imaging @schniering_j @niklasjlang @MDLuecken @fabian_theis bit.ly/3Nee3Au

Very honored to receive the 2025 ISCB Innovator Award at #ISMBECCB2025 and present our lab’s journey—from mapping cells to modeling their future. Thanks to my amazing team and collaborators—this is our award! 🙌 📝 doi.org/10.1093/bioinf…

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. science.org/doi/10.1126/sc… @HsiuChuan_Lin @JasperJanssens7 @TreutleinLab @ScienceMagazine @ETH_BSSE #NGN2 #ASCL1

🤝Excited to partner with Tamarind @kavi_deniz to build towards an agentic AI protein designer. 🔁 Agentic protein optimization — Starting from a sequence, Biomni iteratively improves thermostability by orchestrating AlphaFold-2, ThermoMPNN, and reasoning over predictions and…

👋 Biomni v0.0.4 is now released! In one week of open-sourcing, we have seen amazing contributions from the community: - Multimodal LLM ChatNT @instadeepai as a tool to let Biomni talk with raw DNA/RNA/protein sequence - Added biomedical knowledge graph PrimeKG with millions of…

Everyone missed the real China story. While we debated TikTok, Chinese scientists quietly built 1,250 novel drug candidates—up from 160 in 2015. That's not a typo. They added 1,090 innovative medicines in 9 years. The entire EU added 200. Here's how they broke pharma's…

We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

Happy to share that our work on POPPER — an AI agent for autonomous scientific hypothesis validation — has been accepted to #ICML2025! I’ll be presenting during the poster session this Thursday at 4:30pm — come say hi if you’re around! ⬇️

I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗 nature.com/articles/s4159…

Grok 4 (Thinking) achieves new SOTA on ARC-AGI-2 with 15.9% This nearly doubles the previous commercial SOTA and tops the current Kaggle competition SOTA

🧬 Excited to open-source Biomni! With just a few lines of code, you can now automate biomedical research with AI agent! We are releasing Biomni A1 (agent) + E1 (env) with 150 specialized tools, 59 databases, and 105 software. E1 is our first attempt at curating the bio-agent…

Thrilled to collaborate with Mathew Garnett @Sanger and Parse Biosciences on the new Cancer Plasticity Atlas – a hugely exciting single cell genomics resource to decode tumor adaptation and resistance. 🔗 helmholtz-munich.de/en/newsroom/ne… #CancerAI #Plasticity #Atlas

why don’t we have more medicines? inventing medicines has grown less efficient, limited by our knowledge of biological targets for the 1st time, AI & genomics have the potential to make this knowledge abundant – one of the largest potential impacts of the intelligence age.

🤝Excited to announce @ProjectBiomni × @AnthropicAI! AI agents are set to transform how biologists do everyday research. Thanks to this partnership, the platform is now free for scientists worldwide: biomni.stanford.edu Learn more: anthropic.com/customers/biom…

New OpenProblems paper out! 📝 Led by Malte Lücken with Smita Krishnaswamy, we present openproblems.bio – a community-driven platform benchmarking single-cell analysis methods. Excited about transparent, evolving best practices for the field! 🔗 nature.com/articles/s4158…

🚨New paper on theories of ageing I discuss the major mechanistic theories of ageing in light of recent findings as well as the fundamental nature of the ageing process. Theoretical work is more important than ever in biology, including in ageing. nature.com/articles/s4155…

🧬 1 month update of Biomni: the general-purpose biomedical AI agent! 🌍 Scientists from 2K+ organizations in 76 countries registered 🤖 15K+ research tasks automated — saving millions of biologists hours 💻 12M+ lines of code written 🔥 3B+ tokens burned 🧬 Spanned across…

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. cell.com/cancer-cell/fu…

What a mind-blowing week for AI in biology! 🚀 Xaira just dropped the largest genome-wide perturbation dataset ever last week 🧬 Arc unveiled STATE yesterday, the most powerful foundation model for single-cell perturbation prediction 🧠 DeepMind followed up with AlphaGenome,…

DeepMind just dropped a 106-page paper unveiling AlphaGenome. This single model could completely redefine how we discover disease-causing mutations and drug targets. This is massive. 🧵

AlphaGenome is a key step towards our long-term aim to decipher the genome. We're releasing the model through an API for non-commercial research to empower the scientific community to make new discoveries. Read more about AlphaGenome in our blog post: deepmind.google/discover/blog/…