Stan Huang Lab

@DrSTANtheMAN

Dept of Microbial Infection & Immunity | Pelotonia Institute for Immuno-Oncology | Ohio State University @OhioStatePIIO #CancerImmunology #Immunometabolism

Columbus, OH

Joined June 2013

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Stan Huang Lab@DrSTANtheMAN · Feb 28, 2022

I am thrilled to share that our three years work is finally out ⁦@NatImmunol⁩ ! I’m so proud of my team (esp. PhD student ⁦@lnraines1) and grateful for all the help from our excellent collaborators! #macrophages #ERStress ⁦ nature.com/articles/s4159…

DrSTANtheMAN's tweet card. Nature Immunology - Raines et al. examine the role of the PERK-mediated ER stress response in promoting and sustaining M2-like macrophages in type 2 immune response and in tumor immunity.

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Stan Huang Lab@DrSTANtheMAN · 11 h

Inspired choices recognizing excellence in immunology all around!!! @JeffRathmell ❤️

CCancer Research Institute@CancerResearch · 20 h

🎉CRI is pleased to announce the 2025 recipients of our highest scientific honors, the William B. Coley Award for Distinguished Research in Basic and Tumor Immunology, and the Frederick W. Alt Award for New Discoveries in Immunology! (1/3)

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Stan Huang Lab@DrSTANtheMAN · Jul 23

Early methionine availability attenuates T cell exhaustion ⁦@NatImmunol⁩ nature.com/articles/s4159…

DrSTANtheMAN's tweet card. Nature Immunology - The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents...

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Stan Huang Lab@DrSTANtheMAN · Jul 23

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity ⁦@Nature⁩ nature.com/articles/s4158…

DrSTANtheMAN's tweet card. Nature - An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated...

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Stan Huang Lab@DrSTANtheMAN · Jul 17

Congrats to my superior student #XiaoyunLi and postdoc @sofie_h_moller and all team members. It was a fun journey to work with mycollaborators in Taiwan and Paris. @Ludwig_Cancer @CancerResearch @unil

JJournal of Experimental Medicine@JExpMed · Jul 16

Li, Møller, Ho et al. @unil show how tumor-derived lipids can induce an IL-6–dependent increased glutamine synthesis pathway in cancer-associated fibroblasts, supporting CAFs ability to promote pro-tumorigenic tumor-associated macrophages. hubs.la/Q03xvmfr0

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Stan Huang Lab@DrSTANtheMAN · Jul 17

Great story!! Big congrats, @SanchoLab

WWaggoner Lab@LabWaggoner · Jul 16

Gut bacteria make Imidazole propionate that promotes plaque build-up in arteries @Nature @SanchoLab @annalaura_mstrn Iñaki Robles-Vera nature.com/articles/s4158… nature.com/articles/d4158…

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Stan Huang Lab@DrSTANtheMAN · Jul 17

Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate ⁦@NatImmunol⁩ nature.com/articles/s4159…

DrSTANtheMAN's tweet card. Nature Immunology - Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here...

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Stan Huang Lab@DrSTANtheMAN · Jul 17

Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL ⁦@CellPressNews⁩ cell.com/cell/abstract/…

DrSTANtheMAN's tweet card. While targeting glucose metabolism shows potential in cancer therapy, its clinical implications remain unclear. This study finds that low-carbohydrate diets or impaired glucose metabolism in cancer...

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Stan Huang Lab Retweeted

Marcel Trefny@MarcelTrefny · Jun 27

Very excited to share our review on "Metabolites as agents and targets for cancer immunotherapy" in @NatRevDrugDisc! read it here: rdcu.be/etAMD @SpringerNature @KlinPharm

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Stan Huang Lab@DrSTANtheMAN · Jun 24

Endoplasmic reticulum stress responses in anticancer immunity ⁦@JCubRuiz⁩ @NatureRevCancer⁩ nature.com/articles/s4156…

DrSTANtheMAN's tweet card. Nature Reviews Cancer - The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress...

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Stan Huang Lab@DrSTANtheMAN · Jun 17

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury ⁦@Cell_Metabolism⁩ cell.com/cell-metabolis…

DrSTANtheMAN's tweet card. Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and acceler...

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Stan Huang Lab@DrSTANtheMAN · Jun 11

Early life high fructose impairs microglial phagocytosis and neurodevelopment ⁦@JustinPerryPhD⁩ ⁦@Nature⁩ nature.com/articles/s4158…

DrSTANtheMAN's tweet card. Nature - Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in...

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Stan Huang Lab@DrSTANtheMAN · Jun 2

Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch ⁦@NatImmunol⁩ nature.com/articles/s4159…

DrSTANtheMAN's tweet card. Nature Immunology - Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor...

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Stan Huang Lab@DrSTANtheMAN · May 22

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity ⁦@Nature⁩ nature.com/articles/s4158…

DrSTANtheMAN's tweet card. Nature - A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus...

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Stan Huang Lab Retweeted

Martin Picard@MitoPsychoBio · May 20

The promise of personalized medicine likely lies not in sequencing static molecular genomic features but in our ability to map dynamic metabolic and energetic states go.nature.com/4jWzft2

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Stan Huang Lab@DrSTANtheMAN · May 19

Interferon-γ orchestrates leptomeningeal anti-tumour response ⁦@Nature⁩ nature.com/articles/s4158…

DrSTANtheMAN's tweet card. Nature - Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the...

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Stan Huang Lab@DrSTANtheMAN · May 18

It was a truly inspiring experience to meet with these exceptional immunologists! #FISS2025

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Stan Huang Lab@DrSTANtheMAN · May 16

It’s so much fun to go hiking with Drs. Ellen Rothenberg, Shane Cortty, Coco Chu, Li-Fan Lu, and editors from Science Immunology and JEM in Taipei! #FISS2025

DrSTANtheMAN's tweet image. It’s so much fun to go hiking with Drs. Ellen Rothenberg, Shane Cortty, Coco Chu, Li-Fan Lu, and editors from Science Immunology and JEM in Taipei! #FISS2025

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Stan Huang Lab Retweeted

Eric Topol@EricTopol · May 12

New and concerning finding of brain inflammation and cognitive deficit from CAR T cell cancer immunotherapy but ability to mitigate it is also identified (in mouse model) cell.com/cell/fulltext/… @CellCellPress @michelle_monje @AnnaGeraghty2 @LehiAcosta

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Stan Huang Lab@DrSTANtheMAN · May 10

Congratulations, Hongbo!

SSt. Jude Research@StJudeResearch · May 8

We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.

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Stan Huang Lab@DrSTANtheMAN · May 10

Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer ⁦@lynchielydia⁩ @SciImmunology⁩ science.org/doi/10.1126/sc…

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