Richard Jenner

Excited to be able to offer a project on post-transcriptional regulation of T cell function in tumours in collaboration with @diunguyen_vn_uk as part of the @CRUKCOLcentre Black Leaders in Cancer programme. Please RT!

We have put together great programme for our London mini RNA symposium “RNA in cancer” on 16th July. Hope to see many of RNA aficionados next week at @QMBCI

Architectural RNAs: blueprints for functional membraneless organelle assembly dlvr.it/TLKTCW

1 week left to apply! Please do share, thanks

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale subcompartmental resolution. We resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. shorturl.at/OdUdH

Join us for an in-person mini-symposium to discuss several topics at the interface of RNA biology and Cancer @QMBCI on 16th July. Free to come. Pizza and drink to network! @LondonRNAClub

Excited to share our new paper out today in @MolecularCell! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…

Our revised manuscript explains how Guo et al. concluded PRC2 is not an RNA binding protein. They retained unmappable reads, selectively removed read duplicates from the mappable fraction, and applied an arbitrary cutoff for PRC2 enrichment in RNA. biorxiv.org/content/10.110…

Shifting the pitch and contours of Waddington’s valleys, putative enhancers, and transcription through H3K27me3 chromatin in the endoderm. Find it all here: journals.plos.org/plosgenetics/a…. Fantastic collaboration with @josh_brickman and @wendy_bickmore. Well done Jurriaan and @djmbio.

📢1/12 Thrilled to announce our new preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis biorxiv.org/content/10.110…

QMUL Epigenetics Centre (qmul.ac.uk/epigenetics/) is looking to recruit a senior lecturer with expertise in Genomics/Epigenomics and/or cell-free DNA. This is an excellent opportunity to join a strong Epigenetics and genomics community. Pl share/apply tinyurl.com/yespy6e6

I don’t post here much anymore, but this one is an important announcement for us: 🚨We are Recruiting! So come join us! 🚨#RNA #CancerResearch

🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

🧪 Please share! The Proteomics Team at UCL Cancer Institute is hiring a Computational Scientist to carry out + develop computational analysis of multi-omics data w/ focus on proteomics and phosphoproteomics. Apply by 13 Jan: bit.ly/3VMN7Mi Questions to @Supersurinova

2-year computational postdoc position available to join our growing team to work on super-enhancers & transcription factors in AML @ucddublin. This project will use patient biopsies to identify 'epigenomic' sensitivities for this devastating cancer. conwaychromatinlab.com/team

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Exciting opportunity to come and work with us @uclcancer @CRUKCOLcentre. We are looking for a Computational Scientist for #proteomics to characterise the regulatory phosphoproteome and apply data integration with other multiomics approaches. #TeamMassSpec

Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…

PKM2-G-quadruplex interactions conspire to regulate the cancer transcriptome dlvr.it/TF6mR8