Eimear Lagan
@EimearLagan
Post-doc in cancer epigenetics at the University of Edinburgh
Excited to share our new paper out today in @MolecularCell! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma dlvr.it/TLBcmm
“One of the biggest tragedies I've observed in my professional life.” @davidrliu, winner of the @brkthroughprize in Life Sciences and professor at the @broadinstitute and @Harvard, describes the cost of government cuts to science research at universities. @WalterIsaacson
Congratulations to everyone involved including @EimearLagan, @Dr_RPhillips, @adrianbracken, Gerry Brien and others at @tcdgenmicro, @EdinUni_IGC & @UPenn! Read our web story here: edin.ac/4jeAkLw
Excited to share our new paper out today in @MolecularCell! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma dlvr.it/TKvYxg
One week left to apply for our exciting PhD project 🚨🚨🚨
Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: findaphd.com/phds/project/f… Excited to collaborate with @Hannah_K_Long and @bunina_daria (@EdinUni_IGC @MDC_Berlin). Please share 🙏 #epigenetics
Our lab website is up! We are hiring at all levels. dolanlab-tcd.com
St. Patrick’s Day around the world is a day rooted in community, humanity, friendship and fellowship. Conor McGregor’s remarks are wrong, and do not reflect the spirit of St. Patrick’s Day, or the views of the people of Ireland.
Looking forward to welcoming @PeterLewisLab from @UWMadison for our March webinar on 'Dissecting the Biochemical Complexes Governing Gene Silencing' on March 28th! Register here: us06web.zoom.us/webinar/regist… @activemotif @lisboa_motta
🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇