NEJM

Original Article: Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer (DESTINY-Gastric04 phase 3 trial) nej.md/4k1dwjN #Oncology

Small-cell lung cancer that relapses after platinum chemotherapy has few effective treatment options. The DeLLphi-304 phase 3 trial shows improved survival and symptom control with the DLL3-targeted T-cell engager tarlatamab. nej.md/4kWVuyB

𝐌𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐃𝐍𝐀 (𝐦𝐭𝐃𝐍𝐀) is a circular DNA in the mitochondrion (there are 100 to 500,000 mtDNA copies per human cell) that encodes 22 transfer RNAs, 2 ribosomal RNAs, and 13 protein subunits, all of which are involved in the oxidative phosphorylation…

Katie Watson, JD, discusses the interaction of abortion laws with advance-directive and end-of-life laws. Listen to the full interview with NEJM Executive Managing Editor Stephen Morrissey (@srm128): nej.md/4ohQYxQ

For a 10-year-old boy with elevated BMI, lipid levels, and blood pressure, would you recommend the initiation of statin therapy or no statin therapy? Read the case vignette and essays on both treatment options and cast your vote: nej.md/4kOJijv

Weekend Briefing for July 26, 2025: New Images in Clinical Medicine: Neovascularization in Retinopathy of Prematurity nej.md/44MTZOY Two New Perspectives: 1️⃣ Public Policies, Social Narratives, and Health nej.md/412RDck 2️⃣ Into the Valley of the Sick…

Original Article: “A Vaccine to Block 𝘗𝘭𝘢𝘴𝘮𝘰𝘥𝘪𝘶𝘮 𝘧𝘢𝘭𝘤𝘪𝘱𝘢𝘳𝘶𝘮 Transmission” by S.A. Healy et al. eviden.cc/46a8CN7 #IDTwitter #GlobalHealth

Perspective by Marty S. Kanarek, PhD, MPH: Lead Contamination in Milwaukee Schools — The Latest Episode in an Ongoing Toxic Pandemic nej.md/4187gPJ #PublicHealth

DESTINY-Gastric04 trial: Patients with HER2-positive metastatic gastric cancer have limited options after trastuzumab-based treatment. New phase 3 data show longer survival with trastuzumab deruxtecan than with standard second-line chemotherapy. nej.md/46HZ7W3

After a year of clinical rotations in which a medical student learns to face death up close, her experience on a silent meditation retreat provides her with new perspective on death and life. Read the Perspective by Grace Yi, MSPH: nej.md/4eQLkhD

A 71-year-old woman with systemic lupus erythematosus presented to the ophthalmology clinic for an annual screening examination for hydroxychloroquine-related toxic effects. She reported no vision changes. Read the full case details in the Images in Clinical Medicine article…

A new interactive feature describes a 59-year-old woman who presented to the ED with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. Test your diagnostic and therapeutic skills: nej.md/4mcUHuL

“In May 2023, my first granddaughter, Arlynn, arrived. It was such a thrill, as I’m the mother of three sons. In October 2023, my second granddaughter, Hailey, arrived. I was elated. Whatever heart failure was, I had two phenomenal reasons to beat it.” eviden.cc/44etBfh

Perspective by @nicholas_bagley, JD: Preventive Care at the Supreme Court nej.md/4m2ZaQs #HealthPolicy

Original Article: Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy (QWINT-1 phase 3 trial) nej.md/4jX5R59 Editorial: Weekly Insulins and Therapeutic Burden in Type 2 Diabetes nej.md/4kNIHzB #Endocrinology

A 50-year-old woman presented to the emergency department with a 10-day history of a throbbing headache that had suddenly started after she had felt a “pop” in her back. The headache worsened with upright positioning and improved with lying flat. Physical examination, including…

The authors of a new Perspective argue that real-world data could help advance disease prevention and treatment, enhance quality of care, and empower patients to improve their health. But various challenges continue to impede their utilization. Read the full Perspective:…

Volume 2, No. 8 of NEJM AI is now available! Here are the latest articles:   Editorial: AI-Driven OSCE Preparation in Medical Education: Promise, Pitfalls, and Practical Implications nejm.ai/3GyaXat 🔖 Save for later and share with a friend

Case Record of the Massachusetts General Hospital (@MassGeneralNews): A 75-year-old man was admitted to the hospital because of dyspnea and hypoxemia. CT of the chest showed a cavitary lesion in the right upper lobe and masses in both lower lobes. A diagnosis was made. Read the…

New in the July 24, 2025, issue of NEJM: Fixed-Dose Insulin Efsitora in Type 2 Diabetes (QWINT-1 phase 3 trial) nej.md/4jX5R59 Trastuzumab Deruxtecan in Gastric Cancer (DESTINY-Gastric04 phase 3 trial) nej.md/4k1dwjN Tarlatamab in Small-Cell Lung Cancer…