Luke Jelen
@LukeJelen
Clinical Lecturer in Psychiatry | Brain imaging. Ketamine. Glutamate.
Published today in Lancet Psychiatry, after 7 years of hard labour... the first long-term head-to-head comparison of two augmentation treatments in treatment resistant depression. Clinical and cost-effectiveness of lithium versus quetiapine augmentat... sciencedirect.com/science/articl…
📢A lab’s 1st baby-step is always memorable! First #iEEG evidence that #DLPFC #TMS🧲 evokes responses in #sgACC now out @brainstimj: bit.ly/4mX07ei Huge thanks to @IowaNeurosurg @boeslab @NickTrapp13 @xianqing_liu @DrCoreyKeller @UIowaPeds @UIowaNeuro @NIMHgov 💛🖤❤️
🌿🚨Hot paper alert🚨🌿 Should we be prescribing cannabis to treat acute psychosis?? I actually think it might be a good idea 🤠. Sounds reckless, but cannabis withdrawal syndrome is the only major drug withdrawal syndrome that we don’t treat. And half of psych admissions in…
I want to highlight a finding from (tinyurl.com/37n77d9b) that IMO did not receive enough attention in #psychedelic trial geek circles: it shows that the #placebo effect is much smaller in psychedelic #depression trials than in trials with traditional #antidepressants…
🚨PhD Studentship Available!🚨 Join our lovely team @KingsIoPPN & a super cool project using 7T MRI to investigate glutamate & GABA dynamics in schizophrenia 🧠 Supervised by Prof Alice Egerton, Dr @NickPuts & me! 🚀 Deadline 12th August - pls share! maudsleybrc.nihr.ac.uk/academic-caree…
👉Are you interested in applying brain imaging to better understand the neurobiology of #schizophrenia? We are offering a PhD Studentship in our Experimental Medicine and Novel Therapeutics theme, to start in February 2025. Apply by 12 August (23:59): maudsleybrc.nihr.ac.uk/academic-caree…
The only real psychedelics are tryptamines, lysergamides, and phenethylamines. Ketamine is not a psychedelic. Cannabis is not a psychedelic. MDMA is not a psychedelic. Do you agree or disagree?
The only real psychedelics are tryptamines, lysergamides, and phenethylamines. Ketamine is not a psychedelic. Cannabis is not a psychedelic. MDMA is not a psychedelic. Do you agree or disagree?
Great work @TheBorisLab and team! More on Ketamine +/- Naltrexone mechanisms (in humans) soon(ish) 👀
In 2018, we (w @NolanRyWilliams) found that an opioid antagonist, naltrexone, blocks #ketamine's antidepressant effect. Is ketamine an opioid? What else does naltrexone do? We took these Qs into mice to get some answers, with @mCherryGarcia and many more biorxiv.org/content/10.110…
We have recently treated two cases of treatment refractory mania, that after decades of quality life lost due to inadequate pharmacological treatment both demonstrated profound response to ECT. We are writing up to support the view ECT should be used sooner rather than later
ECT definitely my 1st choice if I had severe depression: 1)By far most effective treatment 2)Quickest/most dramatic response 3)Safer than meds 4)Loss of personal memories time limited All psych & med treatments have benefits/risks- ECT among those with best ratio. Learn more:
We are recruiting to a new 2 year research post in mood disorders - details here! kcl.ac.uk/jobs/085825-re…