Jillian Shaw, PhD

I will give a brief overview on Cell Painting in drug discovery! Free online webinar and Q&A Weds. May 17th 6 pm CET, noon EST, 9 am PST “Discovering Tomorrow's Drugs: How AI and JUMP-Cell Painting are Shaping Pharmaceutical Advances” Register here: ai.ardigen.com/webinar-highli…

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…

If it works in humans, a new epigenome editor could have applications for prion diseases and other neurological disorders like Parkinson’s and Alzheimer’s. trib.al/YAiuA1M

Join us on 4/25 from 4-6:30pm for Rock n' Rare in Kendall Square — music & inspiration for the next generation of rare disease rockstars — a family-friendly event with inspiring stories & live music from the rare disease community. Details: rocknrare.com @broadinstitute

Internship at the Broad on-site in Cambridge MA! - develop methods to interpret microscopy images - apply deep learning - work at the interface of computer science and biology - ~6 months starting June 2024 - BS/masters/PhD student or recent grad Pls RT! broad.io/CSInternship

Delighted to introduce PMF-seq: a new way to link genetic perturbations to detailed bioenergetic phenotypes. We use the method to dissect genetics of mitochondrial ETC branching and acute tBID action. Led by T.L.To ⁦@broadinstitute⁩. nature.com/articles/s4225…

If I had to pick a favorite mountain range…

People with sickle cell disease have new opportunities to eliminate their symptoms, including with a therapy that uses CRISPR gene editing. But the treatments come with obstacles that limit their reach. nyti.ms/3t0qx85

In just a decade #CRISPR genome editing has gone from a new tool to a @US_FDA approved therapy. This approval marks the first of many breakthroughs yet to come in the treatment of human disease; it’s an incredible moment for science and for patients. @VertexPharma @CRISPRTX

Remarkable to see that our discoveries over 15 years ago would enable such tremendous advances for sickle cell disease and thalassemia!!! Incredible to think that the final sentence of our 2008 paper would be prophetic (science.org/doi/10.1126/sc…)... statnews.com/2023/11/16/u-k…

A truly historic moment, first CRISPR therapy approved! Key ingredients: astute clinical observation on HbF and SS (Janet Watson ca 1948), basic developmental biology, human genetics including GWAS for target ID, and of course CRISPR gov.uk/government/new…

Congratulations @AnnaGreka on the fantastic @TEDTalks! Hear from Anna on "The world's rarest diseases — and how they impact everyone." ted.com/talks/anna_gre… @GrekaLab

Awesome preprint from @czbiohub team that builds on #cellxgene to establish a multi-omic annotation workflow. Particularly cool to see how they used the flexibility of the core Annotation tool to include add'l modalities and enable finer annotation. biorxiv.org/content/10.110…

Absolutely over the moon about this Focus issue on the future of bioimage analysis!!! (a short thread)

Our team is excited to invite you to the inaugural Ladders to Cures Symposium focused on efforts to scale mechanisms-focused research in genetic diseases. This hybrid event is July 18, 2023. Please visit broad.io/L2C to register and see the agenda. @broadinstitute

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

An honor to host Dr. Arlene Sharpe today for the Units of Life Seminar Series. To join us at 4 pm, please use the link broad.io/unitsoflife to learn more about the biology behind PD-1 checkpoint blockade @broadinstitute @GrekaLab

Window washing daredevils just set up an epic top rope scaling to the roof of the Broad. I wonder if they’d let me take a lap up this “buildering” route? 5.12+ for sure. 🧗‍♀️

Today we report in @NatureBiotech the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart. 1/4

Congratulations, @AnnaGreka! It was so exciting to see the Greka lab featured on the TED stage. We cannot wait to watch and re-watch the full talk. You're an incredible mentor and scientist!