Ganley Lab
@LabGanley
Autophagy and mitophagy in health and disease
Registration for the joint Autophagy UK & Proteostasis UK meeting is now open. Going to be a great meeting and we look forward to welcoming you to Dundee!
Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with @LabGanley @Rousseau_Lab @mrcppu & @GlennMasson Click here for paper shorturl.at/G0IzL
Very excited to share our new article reporting that #PINK1 has an impact on mitochondrial homeostasis and basal levels of #mitophagy in mouse skeletal muscles, enabling to study the pathway in mammalian tissues without overt stresses. @mrcppu @LabGanley tandfonline.com/doi/full/10.10…
Very happy to have been able to contribute to this new understanding of PINK1 regulation! Great work @miratul_neuro
Just out! Our new preprint reporting interplay between the HRI kinase #ISR_pathway and #PINK1 #mitophagy_pathway. New mechanisms of #Parkinsons disease. 🙏@mrcppu lab members and collaborators @GlennMasson @Rousseau_Lab @LabGanley #TeamScience bit.ly/40y4Xmt
Opposing roles for AMPK in regulating distinct mitophagy pathways. Check out this recent article in @MolecularCell by @LabGanley, Marianna Longo, @AnikethBishnu @Kei_Sakamoto, @CarolMacKintos1 #CellBio2024 hubs.li/Q02_YxPD0
New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: tinyurl.com/AMPK-ULK
We are enormously grateful to the Medical Research Council (MRC)/UKRI for their generous long-term support - 34 years and counting - for our research Unit at the University of Dundee ppu.mrc.ac.uk/news/further-p… @The_MRC @UKRI_News #Dundee
Congratulations to Dr Alan Prescott who won first place in the @Official_BSCB image competition It is a set of tiled images taken from a frozen section of an eye from the mitoQC mouse (McWilliams et al. J Cell Biol. 2016) developed by @LabGanley @mrcppu buff.ly/49TLYqL
Congratulations Philippa @philippajane5 on a successful PhD viva! Well deserved🎉🎉🎉! Many thanks to examiners @VIKorolchuk and @amosliang2 too!
🔬Exciting #JobAlert! 🌟Are you interested in cytoskeletons and their role in organelle biogenesis and autophagy? The @MorelLab4 are on the lookout for a skilled cell biologist to join their dynamic team.🧪 Apply now and be part of cutting-edge research! institut-necker-enfants-malades.fr/index.php?menu…
Congratulations Dr Lorentzen on successfully defending your PhD thesis! Well done and we’ll deserved. Thanks also for the super hand knitted mitochondria hat! Many thanks to examiners @FloreyLab and @farnaby84 too!
We are recruiting! Join the top university in the UK for biological sciences (REF 2021). Appointments for up to 45 Principal Investigators across all career stages (tenure-track to Professorial) are available. Details: buff.ly/3sQcVvJ
Many thanks @MorelLab4 for hosting me, the hospitality and showing the great science that is going on @NeckerInem. I really enjoyed my visit!
enlightening and exciting seminar by @LabGanley today @NeckerInem about mitophagy interplay with AMPK and ULK1.. Thank you very much Ian for your visit to INEM!
Success! First Dundee #Parkinsons patient randomized for Biogen Luminare #LRRK2 kinase inhibitor trial
The Autophagy UK Network Meeting 2023 will be held at University of Birmingham on 19-20 June 2023, organized by @VIKorolchuk and @SarkarSovan, keynotes by David Rubinsztein, @Carmine21678 and @Ivana75154822. Registration link: autophagyuk389582434.wordpress.com
Post-doc position available in Simon Wilkinson’s lab! As a current postdoc in this lab myself, I highly recommend it! And Edinburgh is one of the most beautiful cities in the UK! So if you are interested in ER-phagy, apply now! :) #autophagy @WilkoLabLife elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…
Looking for a post-doc position? Interested in #ERphagy and #Cancer? Then look no further than @WilkoLabLife who have a @CR_UK funded position in beautiful Edinburgh. See below for link & details... elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…
My lab is hiring a CRUK-funded postdoc to work on ERphagy in cancer progression! ppu.mrc.ac.uk/careers/recrui… We are looking for candidates with cancer/cell biology expertise. There is also another upcoming postdoc position to work more broadly on other aspects of ER QC (1/2)
We are looking for a structural biologist with #cryoEM expertise to join the lab. Come join us. We are a fun, diverse and collaborative lab working on interesting questions. Please RT 🙏
Postdoctoral Research (Cryo-EM) position available in Kulathu lab: ppu.mrc.ac.uk/careers/recrui… #Dundee #ubiquitin @YKulathu