Léa Wilhelm

Out Now! Updated story on #HRI kinase as a negative regulator of #PINK1 mitophagy. We now show that the small molecule ISR inhibitor #ISRIB boosts PINK1 activation. Collaboration with @LabGanley @Rousseau_Lab @mrcppu & @GlennMasson Click here for paper shorturl.at/G0IzL

Very excited to share our new article reporting that #PINK1 has an impact on mitochondrial homeostasis and basal levels of #mitophagy in mouse skeletal muscles, enabling to study the pathway in mammalian tissues without overt stresses. @mrcppu @LabGanley tandfonline.com/doi/full/10.10…

NEW. We report on small molecule PINK1 activators that prevent the elevated levels of ubiquitin phosphorylation caused by mitochondrial damage. New insights on the future development of PINK1 activators as new treatments for Parkinson's disease. pubs.acs.org/doi/10.1021/ac…

Very happy to have been able to contribute to this new understanding of PINK1 regulation! Great work @miratul_neuro

SAVE THE DATE!!

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New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in @MolecularCell. Great work from authors, especially Marianna Longo @AnikethBishnu and collaborators @Kei_Sakamoto @CarolMacKintos1. See it here: tinyurl.com/AMPK-ULK

Thomas Williams @DrTomTORC, Adrien Rousseau @Rousseau_Lab @mrcppu @UoDLifeSciences and colleagues identify distinct TORC1 signalling branches that regulate Adc17 proteasome assembly chaperone production. journals.biologists.com/jcs/article/13…

That is Scotland☀️ 🏴󠁧󠁢󠁳󠁣󠁴󠁿 @LabGanley #Lab retreat 🏔

New publication from the Rousseau lab cell.com/iscience/fullt… #Proteasome #Translation #Stress #PhaseSeparation

Due to French industrial action our LeShuttle service is suspended. Customers are advised that, as a consequence of this incident, access to our site is currently unavailable. If you are due to travel today please make alternative arrangements or modify your booking.

New publication form the Rousseau lab ppu.mrc.ac.uk/news/new-mecha… #Translation #Stress #Chaperone #Ribosom

It's great to see our latest story published online! This work has mainly been conducted by my first PhD student, Ailsa Black, who discovered that the ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition.

The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition Adrien Rousseau and colleagues @Rousseau_Lab @mrcppu embopress.org/doi/full/10.15…

Register!!! November 9th at 10am " Monitoring Mitophagy". Dr Aniketh Bishnu, Dr Thanh Nguyen and Kuei-Hsiang Pan (PhD) will be our speakers!!

#savethedate for a technical workshop on monitoring mitophagy. Please check in the comment section for the details. @4womeninscience @BioShirin @VirginieHubert6 @MurielMariDK @GhadaAging

Too much is as bad as too little - Mitophagy - @LabGanley @embojournal #mitochondria #mitophagy #NIX #BNIP3L #FBLX4 embopress.org/doi/full/10.15…

How are specific dysfunctional #mitochondria removed under steady-state conditions? @DienGiang @KeriKozul Yi Cui et al @LabPagan @UQ_News show SCF-#FBXL4 ubiquitin ligase, mutated in MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 embopress.org/doi/10.15252/e…

How do FBXL4 mutations lead to encephalomyopathic mtDNA depletion syndrome 13? Hui Jiang et al find mitochondrial loss & perinatal lethality in Fbxl4 KO mice due to increased levels of mitophagy receptors BNIP3 & NIX targeted by SCF-FBXL4 ubiquitin ligase embopress.org/doi/10.15252/e…

#OpenAccess BNIP3L/NIX regulates both mitophagy and pexophagy buff.ly/3Fa9diV @UoDLifeSciences @mrcppu #Autophagy #Mitochondria #Mitophagy #Peroxisomes #Pexophagy