Luis PENAILILLO
@LPENAILILLO
PhD in exercise and sports sciences/ Interested in Muscle Physiology and Mechanics/ Assoc. professor Universidad Andres Bello
This article examines the metabolic importance of skeletal muscle and its measurement clinically, as well as key genetic and metabolic factors influencing skeletal muscle and the quality of weight loss.
A book chapter we ( @hinksave.bsky.social ) wrote on Sarcomerogenesis and Function. books.google.ca/books?hl=en&lr…
Give me your top 10 on the best one-handed backhands in tennis history! My top 3 is: 1. Federer 2. Wawrinka 3. Gasquet
New Translational Perspective article out in @JPhysiol It was an honour to write it together with @ChrisFryPhD and the one and only Professor Michael Kjaer from @ISMCopenhagen physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
New podcast with @TonyBlazevich out now! With nearly 3 hours of valuable insights into the complexity of skeletal muscle and hypertrophy: youtu.be/Oc0FSbijXb0?si…
🚨 New study in Sci Reports! We found that obesity alters muscle fiber composition and disrupts protein synthesis pathways. Fiber-specific changes in mTORC1, MAPK & mitochondrial proteins p70s6K ↓, ubiquitination ↑ in obesity doi.org/10.1038/s41598… #Obesity #MuscleScience
Latest Podcast: The Science of Cramps🧂vs🏋️♂️ Less about the salt tabs, and more about fatigue & strength! In this episode: ⚠️ Problems with the electrolyte theory 🧠 A Fatigue malfunction instead 💪 Prevention & treatment 🥒 Pickle Power: why it may work 🎧 podcasts.apple.com/za/podcast/the…
This review examines the cellular and molecular mechanisms through which exercise benefits the heart, with a focus on the cardiomyocyte.
Endurance training promotes chromatin accessibility that can be retained! Eluding to other epigenetic modifications that could be involved in muscle memory. It was a pleasure to examine the thesis and pleased to see this finally out in @MolMetab sciencedirect.com/science/articl…
Sarcomerogenesis: "sarcomere division is triggered by tension and local sarcomere damage... and muscle contractions. Sarcomere divisions repair damaged sarcomeres, ensure their mechanical integrity, and synchronize sarcomere addition..." @SchnorrerL science.org/doi/10.1126/sc…
The findings of this one suggest modifications in the skeletal muscle of individuals with obesity that occur in a fiber-specific manner, which may be due to impaired protein synthesis pathways and increased degradation.
The power and potential of mitochondria transfer Nice perspective published in @Nature nature.com/articles/s4158…
👋 Call for Letters - Submit your LTE about “Viewpoint: Durability, Fatigability, Repeatability and Resilience in Endurance Sports: Definitions, Distinctions, and Implications.” Read the Call for Letters requirements: ow.ly/EWyB50WmgLV.
The stimulus is of course not 100% unique to contraction mode (ECC), but rather what triggers the mechanotransduction response that does not really sound all that new to me, nor is it a point of contention BUT - SSN unequivocally increased with ECC exercise in our studies
In this one in survivors of stroke, physical activity doses recommended in the 2011, 2014, and 2021 secondary stroke prevention guidelines were also associated with lower mental health burden, with the optimal exercise dose being 4 to 6 weekly sessions of moderate physical…
Very interesting review by @TonyBlazevich et al on the current evidence about sarcomerogenesis and its application to ecologically valid exercise protocols. Still much we don't know and reason to be cautious when drawing conclusions on the topic 💪 sciencedirect.com/science/articl…