Lorenzo Ferri MD PhD

#ISDE2025, Brisbane, Australia has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 17.5 European CME credits (ECMEC®s)! Learn more 👉isde-congress.net/2025-cme-accre… Register today 👉isde-congress.net/registration/ #esophagus #esophageal

Our new paper in Developmental Cell is now out! A great collaboration from our CRUK Grand Challenge sciencedirect.com/science/articl… STORMing Cancer team showing epithelial/stroma changes in the progression of Barrett's tocancer at the multi-scale,-omic level. @QMUL @QMBCI @CancerGrand

Our work on the progression of Barrett’s esophagus into adenocarcinoma was published in Developmental Cell. Our findings suggest the need for treatment paradigms that go beyond targeting cancerous cells to incorporate stromal reprogramming. bit.ly/41djerh

So excited to see this paper on the stromal changes driving Barrett’s Esophagus progression to Cancer. A Herculean effort effort integrating scRNASeq/CODEX/ECM proteomics. Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics... sciencedirect.com/science/articl…

Conventional therapies often fail in metastatic pancreatic cancer. @MaddipatiLab @utswcancer reviews tumor-stroma interactions that shape metastatic progression in PDAC and highlight potential stage- and site-specific therapeutic opportunities for intervention:…

Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis go.nature.com/4571NLj

Congrats Lorenzo and the entire team this is a beautiful study

nature.com/articles/s4146…

Coupling organoids formed from esophageal adenocarcinoma biopsies with the @wyssinstitute's organ-chip tech, scientists at @RIMUHC1 developed a new tool for predicting chemotherapy responses & testing alternative therapies. wyss.harvard.edu/news/precision…

The integration of scRNASeq, CODEX, and ECM proteomics is truly advancing our understanding of Barrett's Esophagus and its progression to cancer. The interplay between the epithelium and stroma highlights the complexity of the cellular microenvironment in disease progression. It…

Results from the chip "perfectly correlated with the patients’ responses … and their survival rates." Full study by @PalSanjima, @EleeShimshoni, @Kong10Iris, @DonIngber, @LFerri123, et al.: …nslational-medicine.biomedcentral.com/articles/10.11…

📣 Excited to share our lab's latest preprint, detailing a comprehensive study on longitudinally collected GEA patient-derived #organoids #CAFs #TILs. This work represents a significant step forward in modeling GEA-TME & personalized treatment responses.

Posted this now @biorxivpreprint ! A comprehensive effort from @mcgillu detailing progressive refinement of gastroesophageal adenocarcinoma patient-derived #organoid generation. A huge bio repository of almost 400 patient tumours! @organoidscience biorxiv.org/content/10.110…

Very pleased to be part of this important discussion on young onset GICancer at #ESMOGI25. Let's raise awareness!

A gold mine to innovate patient care

In resectable gastric and gastroesophageal junction cancer, adding durvalumab to perioperative chemotherapy improved event-free survival and pathological complete response, with no major increase in high-grade adverse events. Full MATTERHORN phase 3 trial results and Research…

MATTERHORN Periop FLOT+durvalumab 🆚FLOT: ✅Better survival ✅similar adverse events ✅higher path CR ✅similar attrition to surgery Of course there are some issues raised (eg skimming the median) but on the whole this is credible & meaningful improvement patients #tssmn

Congratulations on this milestone! The advancement in generating and refining patient-derived organoids is crucial for understanding gastroesophageal adenocarcinoma. How do you envision this bio repository influencing personalized medicine and drug testing for this type of…

👀👀👀 Fantastic work and an extremely valuable research resource 👏👏👏