Journal of Clinical Investigation
@jclinicalinvest
The JCI is a premiere venue for discoveries in basic & clinical biomedical science. Est. 1924- http://jci.me/qnfji Bluesky: http://jclinical-invest.bsky.social
Conventional therapies often fail in metastatic pancreatic cancer. @MaddipatiLab @utswcancer reviews tumor-stroma interactions that shape metastatic progression in PDAC and highlight potential stage- and site-specific therapeutic opportunities for intervention:…

Congrats to Dr. David Scholten, PhD who successfully defended his thesis on CTC-DPT clusters, accepted by @jclinicalinvest. What a rewarding moment - celebrate with his family/friends, Cluster mates, and our Chair @nupharm1 @NUFeinbergMed @LurieCancer biorxiv.org/content/10.110…
Research by senior author Stephen T. Magill, MD, PhD published in @JclinicalInvest, indicates that a medication typically used for treating Type 2 diabetes may help reduce excess fluid in the brains of patients with #hydrocephalus. Read more now: news.feinberg.northwestern.edu/2025/06/26/dia…
JCI - Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss jci.org/articles/view/…
TRAPα/SSR1 polymorphisms are associated with type 2 diabetes, but the role for TRAPα in islet beta cells was unknown. Ming Liu & team discover Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis in mice: jci.org/articles/view/…

What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment @ColinSh21573670 & @Muirlab @UChicago review nutrient limitations in PDAC, adaptations to metabolic stress, and next steps for revealing critical dependencies and targets: jci.org/articles/view/…

Behind the scenes: Fernanda Laezza @FernandaLaezza and colleagues smiling through poster duty.

A pathway for mitigating pain— @FernandaLaezza & team @utmbhealth report on a FGF13/Nav1.7 protein-protein interaction complex in sensory neurons that can modulate pain in a model of type 2 diabetic neuropathy: jci.org/articles/view/…

Thank you to the Journal of Clinical Investigation for publishing my Lasker Essay.
Congratulations to @shenhanlee @USMintnational on winning the 2025 #LaskerEssay Contest @LaskerFDN! Read his winning essay: Biomedical education in the era of large language models: a paradigm shift: jci.org/articles/view/…
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @ColinSh21573670 jci.org/articles/view/… 1/6
Susceptibility to Mycobacterium tuberculosis is influenced by genetic factors. Joshua J. Ivie et al. @UWMedicine perform a genome-wide association study in myeloid cells and identify multiple variants and pathways associated with clinical tuberculosis susceptibility:…

ICYMI: In pancreatic cancer even localized disease poses a threat to long-term survival due to early metastasis. Brian A. Pedro & @lauradelongwood @HopkinsMedicine review the most common PDAC precursors and highlight opportunities for pancreatic precancer interception.…

Hope this is helpful for folks! Thanks to @BenStanger01 for organizing the series (other articles are awesome!!), reviewers for excellent suggestions and great editorial team @jclinicalinvest . 6/6
ICYMI: Immune landscape in HIV-associated lung cancers— This issue’s cover features work by @BrindaEmu & team @YaleCancer showing the tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV: jci.org/articles/view/… The image…
