Journal of Clinical Investigation

Operable pancreatic cancer is typically paired with systemic treatment to improve long-term survival. John M. Bryant et al. review adjuvant and neoadjuvant systemic therapies and discuss the role for curative-intent radiation therapy in resectable PDAC: jci.org/articles/view/…

Learn more about the winners of the 2025 #LaskerEssay Contest. Check out who inspires them and what’s next in their fields. @LaskerFDN youtube.com/playlist?list=…

Metastatic heterogeneity in pancreatic cancer: mechanisms and opportunities for targeted intervention jci.org/articles/view/…

Research by senior author Stephen T. Magill, MD, PhD published in @JclinicalInvest, indicates that a medication typically used for treating Type 2 diabetes may help reduce excess fluid in the brains of patients with #hydrocephalus. Read more now: news.feinberg.northwestern.edu/2025/06/26/dia…

Conventional therapies often fail in metastatic pancreatic cancer. @MaddipatiLab @utswcancer reviews tumor-stroma interactions that shape metastatic progression in PDAC and highlight potential stage- and site-specific therapeutic opportunities for intervention:…

JCI - Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss jci.org/articles/view/…

TRAPα/SSR1 polymorphisms are associated with type 2 diabetes, but the role for TRAPα in islet beta cells was unknown. Ming Liu & team discover Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis in mice: jci.org/articles/view/…

What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment @ColinSh21573670 & @Muirlab @UChicago review nutrient limitations in PDAC, adaptations to metabolic stress, and next steps for revealing critical dependencies and targets: jci.org/articles/view/…

Behind the scenes: Fernanda Laezza @FernandaLaezza and colleagues smiling through poster duty.

A pathway for mitigating pain— @FernandaLaezza & team @utmbhealth report on a FGF13/Nav1.7 protein-protein interaction complex in sensory neurons that can modulate pain in a model of type 2 diabetic neuropathy: jci.org/articles/view/…

Thank you to the Journal of Clinical Investigation for publishing my Lasker Essay.

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @ColinSh21573670 jci.org/articles/view/… 1/6

Susceptibility to Mycobacterium tuberculosis is influenced by genetic factors. Joshua J. Ivie et al. @UWMedicine perform a genome-wide association study in myeloid cells and identify multiple variants and pathways associated with clinical tuberculosis susceptibility:…

ICYMI: In pancreatic cancer even localized disease poses a threat to long-term survival due to early metastasis. Brian A. Pedro & @lauradelongwood @HopkinsMedicine review the most common PDAC precursors and highlight opportunities for pancreatic precancer interception.…

Hope this is helpful for folks! Thanks to @BenStanger01 for organizing the series (other articles are awesome!!), reviewers for excellent suggestions and great editorial team @jclinicalinvest . 6/6