Kyle Dyson
@Kyle_Dyson
Husband & Father | Neuropathology Fellow @StanfordPath | Physician-Scientist trained @UFMDPhD @Rosen_NeuroOnc | Researching brain tumors + cell & gene therapy.
Congrats @rishabrama and collaborators @MGBneurosurgery on our work developing Meso-CAR T cells for refractory meningiomas, published this week @NeuroOnc! doi.org/10.1093/neuonc…
My weekly read list is back❗️🧵 From computational biology to translational research, 7 reads on genetics, omics, and deep phenotyping 🧬💊🧪 1⃣WGS for all newborns in England 2⃣Perturb-seq atlas of the entire human genome 3⃣Spatial single-cell atlases of human anatomy…
🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed
🚨1/8 Excited to share the final version of our #meningioma #mesothelin #CART-cell paper, now published @NeuroOnc with corrected proofs! This preclinical work lays the foundation for applying CAR T-cell therapy to aggressive and treatment-refractory meningiomas. Highlights ⬇️
Great teamwork at the Pediatric Cancer Immunotherapy Initiative @UFHealthCancer @UFMBI @Rosen_NeuroOnc shows that RNA-lipid particles mediate immune checkpoint inhibition and epitope spreading by early response type-I interferons. nature.com/articles/s4155…
Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing science.org/doi/10.1126/sc…
Excellently written @NatureMedicine review, and honestly the best graphics re: CAR-T toxicities (inc. infections & SPMs) that I’ve ever seen 👏 these will be used in slide decks everywhere! Congrats @KRejeski @JoshuaHillMD @MichaelDJain and thanks for writing this! #MMsm #lymsm
🚨 New in Nature Medicine: “Noncanonical and mortality-defining toxicities of CAR T cell therapy” As CAR-T moves beyond heme malignancies, we need a deeper understanding of rare & long-term toxicities. 🔗 nature.com/articles/s4159… PDF: rdcu.be/ewqLH
Mutant KRAS peptide targeted CAR-T cells engineered for cancer therapy: Cancer Cell @PennMedicine @parkerici cell.com/cancer-cell/fu…
Pan-cancer human brain metastases atlas at single-cell resolution dlvr.it/TLw4ZN
1/11 Our study on subclonal immune evasion in non-small cell lung cancer has just been published in @Cancer_Cell cell.com/cancer-cell/fu…
Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy dlvr.it/TLjvF9
Exciting new paper from @rishabrama @BryanDChoi et al. showing that mesothelin-specific CAR T-cells are effective in meningioma orthotopic xenografts. @NeuroOnc academic.oup.com/neuro-oncology…
New publication! A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis | Science Translational Medicine science.org/doi/10.1126/sc… @ScienceTM
A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice | Science Translational Medicine science.org/doi/10.1126/sc…
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery | Nature nature.com/articles/s4158…
🚨🚨🚨Big news for development of in vivo CAR T cells: AbbVie (ABBV) to Acquire Capstan Therapeutics for $2.1 Billion @abbvie @capstantx #TCell #tcellrx #immunotherapy streetinsider.com/Corporate+News…
Yang et al. engineered iPSC-derived T cells that uniformly coexpressed a CAR targeting a surface antigen, a TCR targeting an intracellular/neoantigen or a tumor-associated antigen or metabolite [...] bit.ly/4ekPaiR @FateThx
Lung cancer survival more than doubles from 2000-2020 due to the collective efforts of precision medicine, immunotherapy, & early detection - 5015pts w lung adenocarcinoma🇫🇷 - mOS 8.5m (2000) v 20.7m (2020) @OncoAlert #LCSM evidence.nejm.org/doi/full/10.10…
The B7H3 drug development space is crowded with ADCs and CAR-T cell therapies are emerging; the therapeutic approaches break out by indication: "The coming B7-H3 tsunami" #oncology #ADC #celltherapy sugarconebiotech.com/insights/good-…
🧠💡 Breakthrough research from our @USCBTC team + @cityofhope published in @Nature Communications reveals how gliomas may outsmart treatment. We used cutting-edge spatial genomics to discover that glioblastomas contain hidden DNA "rebels" called extrachromosomal DNA (ecDNA) that…