Paul Castillo MD
@castillopa5
Assistant Professor, Pediatric Hematology/Oncology and Stem Cell Transplantation @UFHealth. Immunotherapy Researcher @UFBTIP. Views are my own.
Great teamwork at the Pediatric Cancer Immunotherapy Initiative @UFHealthCancer @UFMBI @Rosen_NeuroOnc shows that RNA-lipid particles mediate immune checkpoint inhibition and epitope spreading by early response type-I interferons. nature.com/articles/s4155…
Very nice work Adam and team!
How might COVID mRNA vaccines improve clinical responses to immune checkpoint inhibition? Our fellow Dr. @Adam_Grippin shared findings (Abstract 1037) at #SITC24. Learn more: bit.ly/4gmOF8I @SITCancer #EndCancer
UF Health Cancer Center researchers have found that a genetic alteration may predict the outlook for patients with Ewing sarcoma. Published in @MolOncology, the findings could ultimately help clinicians personalize clinical-decision-making. Read more: go.ufl.edu/51t8cwe
If you are looking for US clinical experience in #neurosurgery, this is a great opportunity! Apply for Neurosurgery Pre-Residency #Fellowship at University of Missouri #Match2025
Apply for Neurosurgery Pre-Residency Fellowship at University of Missouri! Open to US medical students or graduates for 2025-26 academic year. Send your CV or ERAS application to Fania Barsoum [email protected] #neurosurgery
Attention @UFMedicine faculty! The 2025-26 R01 Boot Camp mentee application opens April 1st, 2025! The R01 Boot Camp is a 9-month team-science and mentorship-focused program designed to help faculty member receive R01 or equivalent grants. Learn more at go.ufl.edu/v724ho1.
.@UFHealth pediatric oncologist @JohnLigon has launched a new clinical trial to test a novel @UF-developed mRNA lipid nanoparticle (RNA-LP) in children with recurrent high-grade glioma and recurrent osteosarcoma: cancer.ufl.edu/2025/03/17/uf-…
Happy to share our article in Blood Advances. Great work by grad student Dr. Nam Nguyen, lab alumni Dr. Raffie and current postdoc Dr. Phani Parcha Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide ... sciencedirect.com/science/articl…
Drs. Brenner, Rooney named National Academy of Inventors Fellows. @AcadofInventors @bcmhouston @BCMDeptMedicine @bcmgenetics @BCMCancerCenter @CAGTHouston bcm.edu/news/drs-brenn…
Major congrats @CapitiniMD!
Dr. Christian Capitini has been appointed to serve as the acting director of @UWCarbone. He currently serves as the chief of @WiscPediatrics Division of Hematology, Oncology and Bone Marrow Transplant. He succeeds Dr. Howard Bailey who has served as director since 2015.
IL15 increases the expansion of CAR T cells and induces antitumor responses in patients with GPC3+ solid tumors (i.e. liver cancer). nature.com/articles/s4158…
Amazing work! Major congrats Andras, David and team! @HeczeyAndras @davidsteffin
IL-15-armoured GPC3 CAR T cells for patients with solid cancers nature.com/articles/s4158… @Nature @davidsteffin @AHeczey
📢 We're also looking for passionate grad student & undergrads for #Fall2025 in #PharmaceuticalScience, #ChemicalEngineering, and #BiomedicalEngineering. Apply to @UF_Pharmacy & @UFChemEng! #GoGators #ResearchOpportunity
T cells express a ton of CD5, so why CD5 CAR T cells don't kill each other? Turns out, they completely degrade CD5 protein and thus evade fratricide. Unique mechanism unveiled in a mechanistic study - and PhD thesis work - by Royce Ma: cell.com/cell-reports-m…
Take a look at our newly published article! nature.com/articles/s4169…
Integrated Transcriptomic scores reflective of leukemia drug pharmacology and leukemic stemness predictive of outcome in AML- study spanning >3500 patients from 10 independent cohorts of pediatric and adult AML. nam10.safelinks.protection.outlook.com/?url=https%3A%…
Check out our latest work demonstrating α-CD226 mAbs reduce diabetes in NOD mice by augmenting Treg and reducing effector T cell function. biorxiv.org/content/10.110…
Fantastic and comprehensive review on emerging mechanisms of T cell dysfunction in cancer and strategies to overcome them by @CaitlinZebley @Zehn_Lab @Kyttaro_Therapy @hongbo_chi nature.com/articles/s4159…
Save The Date! Details below for the 3rd annual Cancer Chomp 5k & fundraiser. Bring the whole family for a super fun morning of activities, music, & more! Proceeds to support patients fighting #braincancer @UFNeurosurgery @UFHealthCancer Please repost! #BTSM
Matt Rea was treated with CD19 CART cells back in 2010 at Baylor @CAGTHouston and has been cancer-free since then, for 14 years. The CAR-T were made from his twin brother. Is he the longest surviving CAR-T patient? blogs.bcm.edu/2024/06/04/fol…
Congratulations Dr. Desmond Schatz, Professor of Pediatrics and UF Diabetes Institute Pediatric Medical Director, recipient of the 2024 David A. Paulus Award. Dr. Schatz's passion, expertise, and unwavering commitment to clinical excellence serve as an inspiration to his…