ACIR

Revach et al. recently showed that CD38 drives T cell exhaustion under chronic antigen stimulation and IFN signaling in the TME bit.ly/4mapb0q   @MGHCancerCenter  @oryamush

Sek and Chen et al. demonstrated that overexpression of the adenosine receptor A1R in CAR T cells reduced cAMP levels, and enhanced baseline and antigen-induced cytokine production and effector differentiation. bit.ly/44PEHYr   @PeterMacRes  @paulbeavis4

Humblin et al. showed that sustained ICOS signaling impaired CD8+ T cell survival and function during chronic antigen exposure. bit.ly/46bvdsX  @SinaiImmunol

To overcome the poor persistence and progressive loss of functionality of TCR-engineered T cells, in vivo, Nowicki et al. evaluated tandem treatment with autologous blood-derived T cells and hematopoietic stem cells [...] bit.ly/3GFCHtS @UCLAstemcell @parkerici

Kao et al. showed that at steady state, primary human T cells and T cells from FcγR-humanized mouse strains lacked FcγR expression, except for a small fraction of CD8+ T cells that expressed FcγRIIIa. bit.ly/4kCqsw5  @RockefellerUniv

Phelps et al. investigated mechanisms underlying the positive benefits of exercise on ICI efficacy. In preclinical melanoma, adenocarcinoma, and lymphoma models, exercise promoted functional changes in the gut microbiome[...] bit.ly/4nUyC5S @UPMCHillmanCC @PLRC_PittLiver

Using the MC38 tumor model, Damei et al. showed that CD103+CD8 TRM cells are involved in responses to anti-PD-1 treatment, but not CTLA-4 blockade. bit.ly/4mgbDR9  @inserm

Empowering personalized neoantigen vaccines  @danafarber. Read our digest here 👉 bit.ly/3TIc3U6

Dijkstra et al. generated patient-derived organoid sublines from spatially distinct tumor regions and separate clones within individual regions of 3 NSCLC samples, and also expanded tumor-reactive autologous [...] bit.ly/4nEgwVw  @NKI_nl

Cao et al. demonstrated that the LRRC8A/C volume-regulated anion channel (VRAC) transfers cGAMP from irradiated cancer cells into immune cells within the tumor, and enhances their effector function. bit.ly/40CiNGD

Du, Chen, and You et al. explored mechanisms of LAG3-mediated T cell suppression. Optimal LAG3 inhibitory function required spatial proximity of LAG3 to TCRs (but not the CD4 co-receptor), and was facilitated [...] bit.ly/4eK3CBq  @nyugrossman

Lakshmipathi et al. showed that β2-microglobulin (B2M)-KO (MHC-I non-expressing) melanoma and CRC mouse tumor lines grew rapidly and were anti-PD-L1-resistant when engrafted into immune-competent syngeneic mice. bit.ly/4eK3stO  @YaleMed

Okada et al. engineered and evaluated the efficacy of GPC2-CAR T cells with constitutive production of soluble IL-15/IL-21, membrane-tethered IL-15 and IL-21, or NFAT-inducible expression of membrane-tethered [...] bit.ly/460udI6  @theNCI  @okadar_in_usa

Saillard et al. demonstrated the clinical potential of TCR-engineered CD4+ T cells targeting a broad range of NY-ESO-1–expressing tumors in HLA-DRB3*02:02-positive cancers. bit.ly/3IjvtMs  @OncoUNILCHUV

Mutant p53 doesn’t just lose functionality as a tumor suppressor - it gains new functions that promote an immunosuppressive microenvironment bit.ly/40HZR9s  @kochinstitute  @MGHImaging

Labiano et al. showed that in mice with diffuse midline glioma (DMG), intratumoral co-administration of the Delta-24-RGD oncolytic virus and agonist CD40 antibodies extended survival and induced complete responses in 40% of [...] bit.ly/3Gt1EZa @sara_labiano  @Alonso_Lab

Mi et al. developed an attenuated Salmonella typhimurium strain that harbored a quorum-sensing synchronized lysis circuit (SLC) and overexpressed LIGHT. bit.ly/4l5cN1q

Mohsen et al. showed that a low-affinity LCMV p33-derived A4Y peptide linked to a bacteriophage Qβ virus-like particle induced a robust and specific T cell response, but showed limited cross-reactivity to p33 and failed to protect [...] bit.ly/4kkhtze @MedFacultyUniBE

Zhang and Zhong et al. focused on the role of glycosaminoglycans (GAGs) in regulating T cell responses in the TME. bit.ly/44lg1qk

Hunter et al. developed LNPs for in vivo i.v. CAR delivery, with reduced liver tropism and superior tolerability in rats and non-human primates (NHP) compared to Pfizer’s COVID vaccine formulation. bit.ly/44cJ68J  @Haig_Ag