Shingo Kajimura Lab
@KajimuraLab
Lab at Beth Israel Deaconess Medical Center, Harvard Medical School, HHMI studying bioenergetics. #Metabolism #Mitochondria #Adipocytes @HarvardMed @HHMINEWS
Congratulations to Barbara Kahn for receiving the Roy O. Greep Award for Outstanding research. Nominated by @KajimuraLab.
#NatMetabPicks | In @Cell_Metabolism led by @KajimuraLab et al. (@HarvardMed, @HHMINEWS) C4orf3 is an ER-anchored protein that promotes calcium cycling independent of UCP1 in adipose tissue. cell.com/cell-metabolis…
Congrats to Dr. Shingo Kajimura, recipient of the Outstanding Scientific Achievement Award #ADA2025 whose talk, “An unexpected journey into brown fat research for metabolic health”, just ended #ADASciSession! Happy to have journeyed with him! @AtUcsf @KajimuraLab @AmDiabetesAssn
Beautiful work on PCSK9 as driver of metastatic organ targeting in pancreatic cancer by @GillesRademaker and @rushika_perera just out in @Nature!
Thank you to our wonderful collaborators and their lab members - @RobertoZoncu @YehlabUNC Eric Collisson, the German PDAC consortium, Mark Looney, Bruce Wang, Grace Kim, Kwun Wen - and to @Nature and the reviewers for their thoughtful review of our study.
Congratulations on the 20 years anniversary and thanks for the opportunity!!
Thrilled to share our new @NatureCellBio paper, led by our amazing student @DohunKim96: Mitochondrial NADPH powers mitochondrial fatty acid synthesis to sustain lipoylation, mitochondrial translation, and oxidative metabolism. rdcu.be/eiyH7
New! Online now: Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue dlvr.it/TK5v2N
Adipose tissue generates heat even in the absence of UCP1. How does it work? Our new work identifies a molecular “resistor” of Ca2+ cycling that makes heat and controls energy metabolism through a UCP1-independent mechanism. sciencedirect.com/science/articl…
GLP-1 agonists have transformed life for many people with type 2 diabetes and obesity. The 2025 Breakthrough Prize honors Daniel Drucker, Joel Habener, Jens Juul Holst, Lotte Bjerre Knudsen and Svetlana Mojsov for seminal contributions to GLP-1's discovery, characterization and…
Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain @aakritijain24 and amazing collaborators @rushika_perera, Guido Bommer, Charly Craik and @OlzmannLab: science.org/doi/10.1126/sc…
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism @NatMetabolism Great collaboration led by @SatchinPanda and team! nature.com/articles/s4225…
From “preprint” to “in press”! Congrats @MValdearcos @RachelLippert and the rest of our outstanding team. @AtUcsf @UCSF #microglia #hypothalamus Microglia mediate the early-life programming of adult glucose control: Cell Reports cell.com/cell-reports/f…
“Shunt-ing” down obesity with novel endogenous metabolites dlvr.it/TJTTtH
Thank you! This is an incredible honor. I would like to thank my mentors, colleagues, and all the fellows who have worked with me over the years - Please come join us at ADA in Chicago!
Yay Shingo! • Shingo Kajimura, PhD is the recipient of the 2025 Outstanding Scientific Achievement Award of the ADA, which recognizes research in diabetes that demonstrates particular independence of thought and originality. @KajimuraLab
New! Online now: Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance dlvr.it/TJ6dzg
Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spec-based flux analysis framework to build a whole-body flux model of energy metabolism. Full article access here: authors.elsevier.com/a/1keM55WXUlaX… @yuanbogeneral
Happy to share a preprint on our effort of building whole-body flux models. We integrated the key organismal metabolic parameter CO2 production rate and also its isotope labeling into the in vivo isotope tracing framework.
Ergothioneine is an atypical amino acid to which many health benefits in humans have been ascribed. Here we determine the direct protein target of ergo binding and how it functions in mitochondria and exercise. authors.elsevier.com/c/1kdIa5WXUlaX…
Wow very big news for biomedical research
Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above…