Judith Simcox PhD
@JudithSimcox
Associate Professor @UWBiochem studying lipid signaling and regulation | Co-Director Biotechnology Training Program (BTP) | HHMI FHS
Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
The Jones lab is recruiting for a second opportunity @VAInstitute to study the metabolic underpinnings of autoimmune disease. Details and application portal here: vai.wd1.myworkdayjobs.com/en-US/VAICaree…
Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway | Nature Communications nature.com/articles/s4146…
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the Univ. of Utah their new home to build a metabolic research program. Please share! @uofunuip jobs.sciencecareers.org/job/674355
Essential reading from @DenisPBlondin and colleagues. The thoroughness of the physiological studies is remarkable.
New! Online now: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women dlvr.it/TLy1qc
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @TzuJingYang solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025.0…
Headed to #ENDO2025 this week? Come see us hypothalamic neurogenesis folks! Chaired by @KurraschLab, with me, @DavidPetrik77 and @Carmelo_Quarta at 9am Tuesday!
Discovery of peptides as key regulators of metabolic and cardiovascular crosstalk. Check out this review in @CellReports by @SvenssonLab Katrin J. Svensson & Zeyuan Zhang #ENDO2025 hubs.li/Q03wtQDH0
Check our our recent collab in @NatureCVR ! Congratulations & many thanks to Ieng Lam Lei & @PaulTangMD for the opportunity to be part of such a great project! 🫀💪
Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161… rdcu.be/enbAz
Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.
Research from the James Ntambi and @JudithSimcox Labs reveals an enzyme’s important role in maintaining a healthy balance of lipids in our bodies. More on their latest research: biochem.wisc.edu/2025/07/02/res…
🚨Postdoctoral position available now! 🚨We have an immediate fully funded position available in cardiac metabolism. We are looking for a highly motivated person to lead our animal model work in oxidative metabolism in heart! Pay is competitive with benefits offered. 1/2
Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism & substrate preference in response to time-of-day exercise - HIF1α regulates time-of-day-specific metabolic adaptations, integrating circadian & energetic-induced signals. pnas.org/doi/10.1073/pn…
New paper from @BunkJakub and Mina Ersin in our lab: CKB is the key creatine kinase driving UCP1-independent #thermogenesis in beige fat via the futile creatine cycle (FCC). doi.org/10.1016/j.molm… @McGillGCI @McGillBiochem @MolMetab
Impact of 2 decades of USAID interventions and projecting effects of defunding on mortality up to 2030 "91 839 663 all-age deaths, including 30 391 980 in children younger than 5 yrs, were prevented by USAID funding over the 21-year study period." thelancet.com/journals/lance…
RESEARCH | @kyle_flickinger, @JudithSimcox, @JasonRCantor et al (@Morgridge_Inst, @MorgridgeMeta, @UWBiochem) #NADK as an essential factor for supporting dihydrofolate reductase activity and #folate dependent nucleotide synthesis in #Cancer cells nature.com/articles/s4225…
Congratulations to Professor Alan Attie on being recognized as a @WARF_News Named Professor! Attie has devoted his career to advancing our knowledge of metabolism. Support for the Henry & Annrita Lardy Professor of Biochem is provided by @UWiscResearch: biochem.wisc.edu/2025/06/26/att…