Roberto Zoncu

In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14

Launched today- the Weill Cancer Hub West -supporting transformative cancer research collaborations btw @UCSF & @Stanford. Honored to co-lead, with @longlabstanford, our team who will study the impact of diet on pancreatic cancer initiation, progression and therapy response.

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" We collaborated with @DexeusMujer and employed…

Exciting event coming to @berkeleyMCB ,#MolecularTherapeutics, @MTI_UCB !

Promoted ! 🙌

Final version of our paper showing that a redundant function of several allosteric regulators of glycolytic enzymes HK and PFK is to inhibit the reaction of Harden and Young. Led by @ChoeMangyu in collaboration with Tal Einav and Rob Phillips. A 🧵... (1/) cell.com/biophysj/fullt…

Hard to fathom how anyone can continue to justify the disruption of NIH research by haphazard cuts and destruction when they become aware of stories like this one related to cancer research and clinical trials. cbsnews.com/news/when-is-c…

Exciting event coming to @berkeleyMCB @MTI_UCB !

Congratulations to Elçin Ünal on her promotion to MCB Professor of Genetics, Genomics, Evolution, and Development! 👏🎉 mcb.berkeley.edu/news-and-event…

Happy to present our latest paper with @pottslab & @Amgen in @J_A_C_S by co-first authors @C_M_Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate…

Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen. #MTI #Amgen…

Happy to share our latest paper showing that deletion of adipose-derived Isthmin-1 leads to fatty liver and elevated ceramides. Congrats to first author Saranya Reghupaty and all the co-authors! @MolMetab @StanfordPath @StanfordDRC sciencedirect.com/science/articl…

BREAKING: Fareed Zakaria just gave a masterclass on everything that’s wrong with Donald Trump’s second term policies. This is incredible.

Delighted to share our latest study on the complement anaphylatoxin receptors 😎!!! Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors biorxiv.org/content/10.110…

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by @AMegarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Tweetorial! 1/9 pnas.org/doi/10.1073/pn…

Super happy to share our latest in @NatureCancer co-led by @pannunziolab! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out! nature.com/articles/s4301…

I always love commencement time. So much to celebrate and we get to wear our wizard robes! Congratulations to all the graduates! 👏 🤩

Big congrats to grad students Claire Goul @clairegoul and Julian Yano @JulianYano on earning their PhDs from @berkeleyMCB. Greater adventures await you!

Congratulations Cohen lab alumnus Amit Joshi @amtya21 on his first senior-author paper! Beautiful work! 🎉

Congrats to MCB's Eva Nogales on her election to the Fellowship of the Royal Society! 👏🎉 @royalsociety @NogalesLab royalsociety.org/news/2025/05/n…