Jonathan Weissman's Lab
@JswLab
Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.
Really enjoyed writing this review on the recently expanded landscape of human outer mitochondrial membrane protein biogenesis, its evolution across eukaryotes, and comparisons to the ER biogenesis systems! @JswLab nature.com/articles/s4155…
Excited that the Zhuang Lab is now on X!
Check out our preprint on Perturb-multi (doi.org/10.1101/2024.1…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.
Excited to announce that this work is now live as a first release article @ScienceMagazine So grateful for this fantatic team and to see this work in wild! science.org/doi/10.1126/sc…
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
Hear it straight from our amazing first author @_annhuang to dive into the X-Atlas/Orion dataset and the FiCS Perturb-seq Platform. Excited to share our work from @Xaira_Thera. (biorxiv.org/content/10.110…)
1/12 Excited to share our team's latest work and the first @xaira_thera preprint! Here, we introduce FiCS Perturb-seq, an industrialized platform for generating scaleable, high-quality perturbation data. 📄 Read the preprint: biorxiv.org/content/10.110…
Exciting work from the lab led by @LukeKoblan @KatieEYost @sclerei @WilliamNColgan
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
Congrats @NadigAjay and @Luke0connor!
Congrats @NadigAjay on TRADE out now in @NatureGenet: nature.com/articles/s4158… These statistical metrics enable more meaningful comparisons in Perturb-seq atlases. Also, now find the HepG2 and Jurkat Perturb-seq datasets on GEO GSE264667!
Congratulations to James Numez and collaborators for their RENDER platform for delivering epigenetic editors using engineered VLPs. RENDER broadly advances our ability to deliver epigenome editors into human cells and will likely find ciritcal uses both in fundamental and…
Delighted to share this preprint from Prof. Rong Fan Lab @RongFan8 and Prof. Sidi Chen lab @sidichen on Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT. Congatulations, Alev, Xiaolong, Feifei, Paul, Sidi and Rong!
Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi. biorxiv.org/content/10.110…
Our wonderful collaborators on the Perturb-Multi work (biorxiv.org/content/10.110…) are now here and on the other app, at @ZhuangLab
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…
Very exciting new work on multimodal, in vivo perturb-seq!
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…