Gayathri Muthukumar

Really enjoyed writing this review on the recently expanded landscape of human outer mitochondrial membrane protein biogenesis, its evolution across eukaryotes, and comparisons to the ER biogenesis systems! @JswLab nature.com/articles/s4155…

1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0 science.org/doi/10.1126/sc…

Wonderful to see our work make the cover of the current issue of @MolecularCell! @JswLab @guna_alina Many thanks to @DrawImpacts for the beautiful artwork showing the journeys alpha helical outer membrane proteins make to the mitochondria. Full text link: cell.com/molecular-cell…

Glad to have our work using natural barcode-based lineage tracing to decipher cell states and genealogies of human hematopoiesis out today in @Nature, led by @chenweng1991, a great collaboration with @bloodgenes. doi.org/10.1038/s41586… Check out this terrific thread as well!