Max Wilkinson
@maxewilkinson
PhD @MRC_LMB, now post-doc at @MIT, dabbler in cryoEM. Keen on spliceosomes. Now also keen on reverse transcription. Kiwi.
Such a crazy discovery. I think this captures the reaction of the audience while watching @maxewilkinson present this at the Symposium on the Immune System of Bacteria.
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/
considering making a high-effort molecular movie for an upcoming paper (!) but am slightly worried Twitter / Xitter will implode before I get to post it 🥲
Nils's incredible work is finally out, amazing work on a multi-talented protein by a multi-talented postdoc! It was a joy to use Dari @kimanius 's new Blush algorithm in #RELION to solve the cryoEM structure of this 40 kDa RNA complex
👋🏻 I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published in @Nature. 🥳 This unassuming little helix–turn–helix protein packs quite the punch! 🧶👇🏻 rdcu.be/dNl45
In our newest preprint, • we explore the effects of synonymous genome recoding, and • construct & troubleshoot a synthetic 57-codon E. coli genome using multi-omics, editing, and laboratory evolution. 1/n
The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/@BobQubit, vid @amyneurons, 1/n Published @CellCellPress: cell.com/cell/fulltext/…
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.110… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!
go R2!! 🐦⬛🐦⬛ this is a very lovely study 😍
Bird bird bird, bird is the word! Is the secret to safe gene addition a retroelement in birds? We repurposed the avian R2 element to insert transgenes into human cells (and more!) using RNA-only delivery 🪶 a thread 🧵 nature.com/articles/s4158…
🚨📄PREPRINT ALERT! "New antiviral defences are genetically embedded within prokaryotic immune systems" ⚔️🦠 #phage biorxiv.org/content/10.110…