Florian Praetorius
@FloPraetorius
Biomolecular designer; currently postdoc @UWproteindesign; starting my lab @ISTAustria in March 2024 @flopraetorius.bsky.social
Exciting news part 2: I’m honored and delighted to announce that the Praetorius lab for Biomolecular Design @ISTAustria has been awarded an #ERCStG (before even starting) for “Design of Nucleic Acid-templated Ordered Protein Assemblies”. @ERC_Research
Anna and Sam are X-less but they’ve done some excellent work with this project. It’s a very exciting time for enzyme designers!
New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.…
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis…
“Science is a human activity.” The week before chemistry laureate David Baker visited Stockholm to receive his Nobel Prize, his 101st PhD student had just graduated from his lab. For Baker, doing great science is about collaboration – he puts great effort into fostering a…
After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton @hendrik_dietz biorxiv.org/content/10.110…
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @hendrik_dietz we showed how we can drastically improve AF2 based hallucination, surpassing, or reaching SOTA diffusion models doi.org/10.1126/scienc…
So delighted to have this finally online! In our newest preprint we are detailing the computational design of a catalytically active helical barrel protein with a highly engineerable central channel. Check it out! biorxiv.org/content/10.110…
Excited to join the Gene Center at LMU @GeneCenter_LMU @LMU_Muenchen as a professor, looking forward to design some cool and unusual de novo proteins here!
🥳 We welcome Lukas Milles as new group leader🤗🤗! Since July 2024, he's leading an Emmy Noether Research Group at MPI Biochemistry, now also affiliated with us! 💻🧪 His work focuses on protein design, deep learning & biophysics. genzentrum.uni-muenchen.de/research-group… @LFMilles @MPI_Biochem
I am looking for a partner in crime who actually understands biology in Vienna — join Aithyra to make some magic oeaw.ac.at/aithyra/news/s…
#MERS vaccines built on our two-component protein nanoparticle platform induce robust neutralizing antibody responses and protect mice against vaccine-matched challenge. This collaborative project was led by @chao_cara and is out now on @biorxivpreprint: biorxiv.org/content/10.110…
Three @ISTAustria scientists have won @erc_research Starting Grants #ERCStG! A combined 4.8 million euros will go to @MMondelli, @aliciakmichael, and @lisa_Bugnet. Read more about the scientists and their projects 🔗 bit.ly/3XvfQXo
Hot off the press: New paper about computational design of oligomeric proteins that can be triggered to change size and shape through allostery. Check out the beautiful thread by @ArvindSPillai1 !
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others! nature.com/articles/s4158…