Evan Weber

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/ nature.com/articles/s4158…

BREAKING: We uncovered a potent immune alliance that could change how we treat solid tumors. Published in @Cancer_Cell , we show that Th17 cells *must* work with B cells to eliminate tumors—and keep it from coming back. 📄 cell.com/cancer-cell/fu… 🧵1/12👇Let’s walk through it:

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…

🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed

Review @JCI_insight Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering insight.jci.org/articles/view/…

The T cell subsetting challenge dlvr.it/TLrRl9

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

Exciting work from the Beavis and Darcy labs using endogenous promoters to drive tumor-restricted CAR T responses. Congrats @paulbeavis4 and team!

Great opportunity and a great city!

We are looking for talented postdocs/visiting students to join our team @MITdeptofBE and @kochinstitute to innovate spatial multi-omics technologies, map clinical samples, and integrate AI/ML models to advance next-generation cancer immunotherapy. Please help to spread!!

This is wild. Unclear mechanistically how it might happen, but this provocative study showed that cancer-associated neurons transfer mitochondria to the cancer cell to induce metabolic reprogramming and increase metastasis. Dr. G Ayala @GreletLab @Nature rdcu.be/etpZ6

We’ve been talking about CAR T day for a few weeks now… and you still haven’t registered? Let’s shine a light on some of the exceptional speakers joining us to share their groundbreaking work and insights. This is the first in a 6-part series 🎯 🎙️ Meet: ➡️ Justin Eyquem (San…

We previously showed that IFNg is required for CAR-T efficacy in solid tumors, but is it always good? Here, we show that IFNg limits CD28 CAR-T cells and that protection from this signal drives greater antitumor activity and durability. Enjoy! science.org/doi/10.1126/sc…

12/ Bioinformatics isn’t about blindly analyzing big matrices. It’s about asking: “What’s the signal? What’s the noise? And what can I ignore to see the truth?” That’s the real art of dimension reduction.

Incredible advocacy from @parkerici investigators Crystal Mackall (@StanfordMed) and Carl June (@PennMedicine) at the @FDA Cell & Gene Therapy Roundtable—fighting for kids with cancer. Grateful to @HHSGov for bringing the full team to tackle regulatory, funding, and payor…

Important findings on overcoming dysfunction in engineered NK cells. Congrats!

🧵1/ T cells have deservedly been in the🔦for #cancer #immunotherapy, but other engineered cell therapies are now📈. What mediates NK cell exhaustion remains an important unanswered❓. 📄Link: nature.com/articles/s4158… I’m so thrilled🥳to share our work out now🚨@Nature…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

The FY26 HHS Budget in Brief has been released. It outlines how the existing NIH institutes & centers will be combined into eight (with only NCI, NIA & NIAID retaining their original structure). There are 40% cuts proposed in NIH budget (including the NCI). 😢 Cancer Research 📉

Excited to share the first of many works out of @JJMilnerLab. Be sure to check it out! Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment: Immunity cell.com/immunity/fullt…

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…