Zihai Li, MD, PhD
@Zihai
Founding Director, Pelotonia Institute for Immuno-Oncology (@OhioStatePIIO) • Deputy Director of @OSUCCC_James for Translational Research • Views My Own
Are #NK_cells friends or foes in cancer #immunotherapy? We found they impede the development of anti-tumor NK-regulated T cells (#NKRTs). doi.org/10.1158/2159-8… A separate study by @lab_marine showed that NK cells contribute to ICB resistance in melanoma. doi.org/10.1158/2159-8…
Yet another layer of complexity of NK cell biology and clinical translation.
Data suggest that eliminating NKG2D signaling could be beneficial in NK cell adoptive therapy, highlighting the need to better delineate downstream effects of NKG2D in humans rather than in mice before developing new #immunotherapy. Learn more: ow.ly/nCOj50WlLrM.
AI or not, NIH limits scientists to six applications per year science.org/content/articl…
Kudos to the international team from 🇨🇳 & 🇺🇸 that conducted this important study published in @Cancer_Cell Brain metastases are one of most dreaded complications of advanced disease. Pan-cancer human brain metastases atlas at single-cell resolution cell.com/cancer-cell/ab…
Pursue original research not citations. share.google/ZQVNXLAGzOr3iC…
Very pleased to host @MengzeLv during his visit to @OhioStatePIIO.
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy: Cell cell.com/cell/fulltext/…
NIH announces end to funding for animal-only studies drugdiscoverytrends.com/nih-announces-…
ICYMI: Vaccines in cancer treatment and prevention: the time is now: jci.org/articles/view/… In this viewpoint, William Becker & @KimrynRathmell suggest that cutting‑edge mRNA neoantigen-based vaccines can train the immune system to better detect and eliminate cancer cells.
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity. cell.com/cell/fulltext/…
#LabMeeting 6/26/2025. Really proud of folks in the lab. #Passion #Purpose #Impact #CancerResearch @OhioStatePIIO @OSUCCC_James @Pelotonia
A win for science and humanity! !science.org/content/articl…
This is wild. Unclear mechanistically how it might happen, but this provocative study showed that cancer-associated neurons transfer mitochondria to the cancer cell to induce metabolic reprogramming and increase metastasis. Dr. G Ayala @GreletLab @Nature rdcu.be/etpZ6
#ScienceSaturday ❓Why don’t some immune cells perform well in the fight against #cancer? ➡️ In this study, No-Joon Song et al. found that certain natural killer (NK) cells inside tumors can actually block the growth of the CD8+ T cells we need to fight cancer, while allowing…
A subset of tumor-associated NK cells restricts checkpoint blockade sensitivity by impeding a ROR-α–dependent cytotoxic CD8 T-cell differentiation program via competition for IFNα & IL-2 @CD_AACR @Zihai aacrjournals.org/cancerdiscover…
A new Science #Immunology Review examines the multifaceted ways in which T follicular helper cells modulate immune responses during infection, #allergy, and #autoimmune diseases. scim.ag/3SQqyoq
Congrats to Dr. Peter J. Mohler @PeterMohler on his appt to the 30th President of The University of Alabama news.ua.edu/2025/06/dr-pet…
NEW content online! Neuro-immune cross-talk in cancer bit.ly/3TuULJG