Koichi Takahashi

🚨 New paper in @NatureGenet ! How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here! nature.com/articles/s4158…

Cancer therapies impose a selective bottleneck that predisposes patients to developing clonal hematopoiesis. A review by @DrKTakahashi @NakadaLab & @Goodell_Lab reveals the distinct clinical implications of therapy-related clonal hematopoiesis.

自分が筆頭著者の論文がBloodに公開されました！血液・腫瘍関連の人は読んでね。他分野の人はフィギュアだけでも見てね。 Fusion Oncoproteins and Cooperating Mutations Define Disease Phenotypes in NUP98-Rearranged Leukemia | Blood | American Society of Hematology ashpublications.org/blood/article/…

Very excited to share our paper investigating the evolution of therapy-related CH in myeloma pts treated w/ or w/o LEN. Can we predict the risk for second blood cancer in myeloma pts? Grateful for the collaboration with @UCCancerCenter myeloma program. nature.com/articles/s4137…

Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…

Happy to share our newest work out today in BCD evaluating disease classification and prognosis in the “world of myeloid malignancies”! Wonderful collaboration with @sanamloghavi @PapaemmanuilLab @Elsa2Bernard and colleagues.

Detecting and quantifying clonal selection in somatic stem cells | Nature Genetics. So pleased to share this work. It is one of the most important pieces of work we have done. Huge thanks to all. More improvements on SCIFER to come! nature.com/articles/s4158…

What lasting effects does chemotherapy have on healthy blood-forming stem cells? MD Anderson researchers examined the effects of several chemotherapy drugs on patients with multiple myeloma. Learn more: spr.ly/60194YG6B #EndCancer

Cancer chemotherapy does a number (as in mutations) to blood cells 2 new reports using single-cell sequencing show the deleterious effects of these drugs, yet another reason for better therapeutic approaches nature.com/articles/s4158… nature.com/articles/s4158… nature.com/articles/s4158…

Read more about team Mutographs paper in this @NatureGenet news and views piece, which also highlights the work of @DrKTakahashi and colleagues 🔗nature.com/articles/s4158…

👉👉👉Proud to share our brand new paper 📑 🚨 just out in @BloodJournal ➡️ ➡️➡️ collaborative multi-disciplinary #HowITreat #BPDCN with focus on SCT #bmtsm #leusm #RareDisease 👉 .@MKD_BMT .@lane_andy @doctorpemm | @MDAndersonNews #endcancer 🙌 doi.org/10.1182/blood.…

Another review published in @jclinicalinvest ! This time with dearest friends and collaborators @Goodell_Lab and @NakadaLab. We reviewed the landscape of therapy-related clonal hematopoiesis. How it develops and differs from de novo CH. jci.org/articles/view/…

I really like this schematic from @DrKTakahashi at #iWAL24 on phenotypic shifts in AML after ven-based therapies … don’t underestimate the tiny monocytic & erythroid clones.. they will come back & haunt you!! Food for thought for us #hematopathologist we need to report and track…

👉👉👉Clonal evolution of hematopoietic stem cells after cancer chemotherapy| @bioRxiv | led by ⁦@DrKTakahashi⁩ | ⁦@jyoti_nangalia⁩ ⁦@Transplant_Doc⁩ ⁦@Goodell_Lab⁩ ⁦@NitinJainMD⁩ ⁦@kanagalshamanna⁩ ⁦@garciamanero⁩ biorxiv.org/content/10.110…