Kelly Bolton MD PhD
@KellyLBolton
Mom, Physician, Scientist at Washington University in St Louis
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…
This shifts the focus from just tracking CH mutations to asking: who's primed for progression before CH even starts? This could help refine risk stratification beyond just ‘high-risk’ vs. ‘low-risk’ CH driver genes.
Congratulations to @KellyLBolton and colleagues on this important new study in @NatureGenet, showing how germline variation, including in #RUNX1, influences clonal hematopoiesis and the risk of hematologic malignancy. We’re grateful for research like this, which deepens…
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…
Bravo @KellyLBolton - can’t wait to read this!
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…
Congratulations, all, on another seminal contribution - improving risk prediction of hematologic malignancies!!! 👏🏻👏🏻
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…
Congratulations @KellyLBolton !!!
congrats Kelly! I really enjoyed learning from your work!!
These germline-somatic interactions are probably quite complex and context specific. But I think it emphasizes the need to take into account germline variation when we conduct both observational and interventional CH studies.
Great thought Aju. Honestly I think we would need more data in pgv carriers getting chemo in order to answer that. We have a paper under review where we did CH serial sampling in patients getting PARPi. Surprisingly we saw less TP53-mutant expansion among HRD carriers!
Day 2 of the #2025PPLC begins with Dr. Wei discussing Bleximenib in KMT2A & NPM1 altered AML f/u by @LuskinMarlise @LoriMuffly & others kicking off the ALL session. Grateful for my wonderful colleagues & friends who made me feel special on my birthday! ❤️❤️❤️@sanamloghavi
Congratulations @KellyLBolton @pnatarajanmd and team!!! Brilliant work.
This is super informative. Thank you and congratulations!!
Also deeply thankful to @AlexBickMDPhD, @pnatarajanmd, @jrblundell, @nilanjan10c, @carolinewatson, @hamish_macg, @DrFlashHeart, @yincaoScD, @bloodgenes, and many others for their incredible collaboration and support! Please see the full author list here 👇
Truly grateful to lead this study during my PhD @WashUdbbs @WashUCancerBio. This project challenged and shaped me as a scientist in every way. Huge thanks to @KellyLBolton for amazing mentorship and honored to be part of the Bolton Lab! kellyboltonlab.org
Can your inherited DNA determine how fast mutant blood clones grow—and whether they cause cancer? Yes, certain germline variants both fuel clonal expansion and multiply the risk of progression to hematologic malignancy. CHEK2 and ATM stand out. 🔗 nature.com/articles/s4158…
Can your inherited DNA predict which blood mutations you'll get—and shape your CH landscape? In our analysis of 731,835 individuals, we discovered 22 germline genes that not only influence clonal hematopoiesis (CH) risk but also determine which somatic driver mutations arise.
Clonal hematopoiesis (CH) is when blood cells carry mutations. It’s common with age—and sometimes a warning sign for cancer. But not all CH is equal. Why do some people progress, and others don’t? Check out @KellyLBolton’s excellent thread and our paper here @NatureGenet 👇