paresh vyas

Check out Verena’s tweetorial Please do use SCIFER. Just needs bulk WGS data to infer selection from drift and give you stem cell dynamics Multi clone SCIFER coming soon Multi clone SCIFER with stem and progenitor cell dynamics in the works!

SCIFER is broadly applicable to whole genome sequencing data from somatic tissues and available here: github.com/VerenaK90/SCIF…

We then studied WGS data from human brain, finding pervasive clonal selection emerging early in life. In 2 cases, selection was associated with mutations known from brain cancer, suggesting pre-neoplastic expansion. For most cases, however, the cause of selection was unknown.

Our paper on detecting and quantifying clonal selection from a single bulk sequencing sample is out! This was a great collaboration with @pvyas_oxford, Thomas Höfer, @asger_jakobsen and @NaserAnsariPour. Read the full story here: nature.com/articles/s4158…

Detecting and quantifying clonal selection in somatic stem cells | Nature Genetics. So pleased to share this work. It is one of the most important pieces of work we have done. Huge thanks to all. More improvements on SCIFER to come! nature.com/articles/s4158…

Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome ashpublications.org/blood/article/… 10 year project with Irene Roberts and numerous collaborators. Natural history of myeloid preleukaemia and leukaemia in newborns and young children with T21.

Thank you for this wonderful and impactful collaboration @AlejoFraticelli and Lars Velten!

Congrats Ari. So pleased!

Fantastic collaboration with Dan and Puneet! Thank you so much!

In a good cause!

I’ve had the privilege to train with Peter Marks. I’ve met truly exceptional physicians before/since, but I’ve yet to meet one so devoted to patient care, excellence, and with so much integrity. He saw every patient before we interns pressed the first snooze, always with a smile

Great work Ross, Bobby and the team. A look ahead at informative next gen models.

Congrats Eirini! Great work! Impactful+++

Submit an abstract by November 18 for the AACR Special Conference on DNA Methylation, Clonal Hematopoiesis, and Cancer (February 1-4, San Diego), chaired by Stephen B. Baylin, Margaret A. Goodell, and Peter A. Jones. bit.ly/48miPFr #AACRmethylation25 @Goodell_Lab

📻 Listen to @BBCR4today, highlighting Cambridge’s excellence in cancer research as it receives £173 million from @CR_UK for @CRUK_CI (starts 2:41:09). #ChangingTheStoryOfCancer #Cancer #CancerResearch bbc.co.uk/sounds/play/m0…

Congrats Jamie Richly deserved Fantastic appointment for Cambridge

The countdown has started for our “Advances in nuclear topology and 3D chromatin architecture” one-day Symposium! Check out the list of impressive speakers and Register! Organized by @jane_skok #epigenetics #cancer #transcription

Immunologists out there, join us in New York City and @nyugrossman !! All candidates will be considered but the ones with a track record in the development of cutting-edge experimental, engineering and computational approaches to analyze immune responses are particularly…

Recruiting faculty to the Dept of Molecular and Cellular Biology at Baylor College of Medicine in Houston, TX! Recruiting broadly in cancer and cell biology. Submit by October 1, 2024, for full review. #cellbio @BCMhouston bcm.edu/departments/mo… jobs.sciencecareers.org/job/659987/ten…

We have open faculty positions in the area of Tissue Regeneration, Metabolism, and Cancer. Stellar place to work for sure!!