Cat Mak
@CatMak23
Cool new study from @KajimuraLab showing ALN acts as a molecular “resistor” to SERCA2b calcium transport, driving UCP1-independent thermogenesis and helping regulate energy balance in adipose tissue 🔥
Adipose tissue generates heat even in the absence of UCP1. How does it work? Our new work identifies a molecular “resistor” of Ca2+ cycling that makes heat and controls energy metabolism through a UCP1-independent mechanism. sciencedirect.com/science/articl…
This morning at #BCVS25, undergraduates took part in a hands-on CPR class building lifesaving skills alongside their scientific training 🫀💪🏼 Many thanks to @BCVSearlyCareer and @American_Heart for supporting this initiative 👏🏼
Some of what makes each of us unique is likely to be expressed in mitochondria Discussion on a new paper here: mitoworld.org/how-evolution-… The paper: cell.com/cms/10.1016/j.… Probing the role of mitochondria as driver of psychobiological differences in humans:…
Kicked off #BCVS25 with a wonderful networking dinner with undergraduate students from summer programs across the country❣️ Looking forward to an exciting week of science with @American_Heart and @BCVSearlyCareer 🤩
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…
📢 We are looking for a driven junior postdoc to join our group! If you have research experience in cardiovascular physiology, calcium signaling, or ion channels, please reach out 🫀🔬 [email protected]
We escaped!🧩🔑Challenge conquered thanks to solid teamwork 👏🏼 Always fun to see our lab skills put to the test in a unique way🧠🤓 @aarongibson55 @Taylor_coughlin @OmarBritoStrada @joseph_verry @cariswaddinglee @olivia_gittens1 Mike Kamradt, Martin Lopez-Isidro & Emma Linkugel
Exciting opportunity for researchers passionate about #mitochondria. Join us at @dukenus to explore mitochondrial #microproteins in metabolic control. Use AI to uncover therapeutic targets for metabolic diseases from the microproteome. @Mito_News nature.com/naturecareers/…
Yesterday we celebrated @YutzeyLab 's upcoming retirement from @CincyKidsHeart 🎉 We are beyond grateful for her unwavering dedication, mentorship & service over the years. She will be deeply missed and leaves behind a legacy of science & friendship 🫀🧬🔬 Yutzey out✌️🏼
🚨 New review alert! #MakLab postdoc @cariswaddinglee explores the emerging roles of #microproteins in metabolism, signaling, and disease. Small peptides, big impact! 🧬⚡️ Check it out here 👇🏼 mdpi.com/2073-4409/14/1…
Missed the deadline? Plot twist: You didn't! Deadlines extended! 🗓️ #AHA25 & #ReSS25 abstracts now due 6/9 at 10am ET. Award applications due 6/9 at 7pm ET. Submit here: 🔹 AHA: bit.ly/2025Extension 🔹 ReSS: bit.ly/ReSSExtension
Maarten van den Hoogenhof found a specific way to improve cardiac function in RBM20 cardiomyopathy. CAMK2 inhibition might become the first tailored therapy for a Dilated Cardiomyopathy (after mavacamten for Hypertrophic Cardiomyopathy): biorxiv.org/content/10.110…
Grateful to work with so many talented and passionate people to build the foundation for how we think about mitochondria, energy, health, and healing Kudos @AnnaMonzel for coming up with the "motherboard" analogy Thank you @janellison scientificamerican.com/article/why-mi…
@CircRes May 23rd Issue is Out! Compendium on Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases In this issue read 14 reviews & 5 Research Letters: ahajrnls.org/4kaMnLo @gabrieleschiat1 @mkontari
What an incredible evening at yesterday's Presidential Dinner in Iraka, Nara! 🥢✨ The traditional Japanese wadaiko drumming performance and hands-on mochitsuki (rice cake pounding) absolutely captivated everyone's attention! #ISHR2025
🚨 Calling all #EarlyCareer scientists! 🔬 Want to dive into cutting-edge –omics research? Join top experts from @UCSanDiego, @UWMadison, @UIowa, @CedarsSinai + more! 🗓️ Wed, May 7 | 3–4:15pm EST 🎟️ Free with AHA membership 👉 bit.ly/BCVSEC #CardioTwitter @AHAScience
📢 We’re Hiring! arizona.csod.com/ux/ats/careers…
🚨New review out in Seminars in Cell & Dev Biol written by rockstar PhD student @Taylor_coughlin👏🏼 We explore the emerging roles of ER #microproteins in Ca2+ signaling, organelle crosstalk & disease. Small but mighty 💪🏼 & full of therapeutic potential🧬👩🏼🔬 sciencedirect.com/science/articl…
The internal architecture of mitochondria, site of energy transformation in the cristae, become aligned *across* organelle Evidence of information exchange across organelles 🧵
Cristae may not only produce energy...their charge gradients, creating a dipole, may generate EM field topologies that regulate intracellular communication in real time. Their alignment, as shown by @MitoPsychoBio, might serve as a physical code for mitochondrial state, with…