Lena Ho
@Holab_DukeNUS
The Endogenous Peptides Lab discovers and deorphanizes bioactive microproteins that regulate mitochondrial metabolism
First crispr screen by rockstar postdoc Jiemin Nah @Holab_DukeNUS to uncover microproteins required for mitochondrial metabolism. #mitochondria #microproteins Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation: Molecular Cell…
Cool study on how a mitochondrial microprotein regulates mt-RNA metabolism: Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma: Molecular Cell cell.com/molecular-cell…
Exciting opportunity for researchers passionate about #mitochondria. Join us at @dukenus to explore mitochondrial #microproteins in metabolic control. Use AI to uncover therapeutic targets for metabolic diseases from the microproteome. @Mito_News nature.com/naturecareers/…
Just concluded the amazing 2025 Keystone meeting on Microproteins in Beverly, MA. Thank you Thomas Martinez and Anne-Ruxandra Carvunis for curating such an outstanding program. A special shout-out to Sarah Slavoff for an inspiring keynote lecture. @SlavoffL @carvunis @tfmPhD
We’ve wrapped up another fantastic meeting, celebrating the achievements of our award winners & the successful conclusion of our Microproteins conference! Congrats to Carly Houghton, @JuveriyaQamar , & Achala SF Vitharanage. @tfmPhD @carvunis #keystonesymposia #keystoneawards
What are respiratory supercomplexes (SCs) doing? Our collaboration with @Holab_DukeNUS shows that an extra large SC forms between complex I and complex III in a mouse model of complex III deficiency. SC-XL rescues the respiratory defect. sciencedirect.com/science/articl…
Ever wondered why we need respiratory supercomplexes? New findings from our lab, in collaboration with @LettsScience, show how a specialized supercomplex - the SC-XL - can help mitochondria overcome some respiratory defects & provide cardioprotective benefits. Studying…
Did you know that the fetal immune system can protect from congenital infection before birth? -Proud to share our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection.
Now online! Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection dlvr.it/TG7FfY
Working with a great team to organize @KeystoneSymp #Microproteins: from Discovery to Applications! Abstract deadline is Nov 6th. Please submit your exciting work and join us in Beverly, MA, USA in Feb2025! keysym.us/KSMicroprotein… #KSMicroproteins25
Big roles for small peptides! I’m so excited to share my work in the @PerrimonLab on mitochondrial “Sloth” peptides 🦥🦥, out now in @eLife, explanation thread below elifesciences.org/articles/82709 1/16
In @JExpMed, Nadkarni, Chu, Lee, et al @Holab_DukeNUS show that CARD8 #inflammasomes are activated by Coxsackie B3 protease-mediated cleavage. Knocking out CARD8 attenuates CVB3 propagation & dampens #inflammation in a cellular model of viral #myocarditis.bit.ly/3Ut2ash
Catch Bruno @reversade live on radio today discussing our recent work on mutations in the gene FOCAD that causes acute liver disease in children. Live on radio CNA938's Health Matters at 4:10pm Singapore time (9:10 am BST or 10:10 am CET) channelnewsasia.com/listen @astar_gis
Registrations are now open for AussieMit 2022! Secure your spot today for the meeting on 16-18 November, at the University of NSW, Sydney, Australia.
Cooperative assembly of the mitochondrial respiratory chain cell.com/trends/biochem…
We are hiring! Postdocs interested in cool new mitochondrial peptides please see nature.com/naturecareers/…
Singapore scientists discover new peptide that contributes to "elegant mechanism" body has in place to prevent excessive, potentially tissue-damaging inflammation during infection, such as cytokine storms #dukenus bit.ly/2RZ9vo1 via @dukenus @EurekAlert