Genome Stability Lab
@C_K_Schmidt
Understanding and exploiting genome stability & DNA repair mechanisms, ubiquitin/UBLs, cellular micromotors, bioengineering (University of Manchester)
Congratulations to Dr Zac Sandy for passing his viva today 🎓🎉🎊🍾🥂 A big thank you to the examiners Drs Stefan Meyer and Alex Garvin for their help, time and excellent examining, and thank you also to Kiran Batta for jumping in as independent chair in the last minute!
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2…
If you think the next big idea in your field will come from inside the field, you're probably wrong.
Closing soon - ACED Non-Clinical PhD Studentship. 🚨 💰Fully-funded for 4 years 👩🔬Learn from leading cancer researchers 🏥 Rotate your training across various ACED Centres 📅 Deadline: Monday 4 November 🔗 Apply: ow.ly/WGIW50TtugI
Applications are open for our Clinical & Non-Clinical PhD projects! 🧬 Access state-of-the art facilities 🌍 Learn from world-leading academics 🐝 Study in the buzzing city of Manchester 📆 Deadline: 15th November Explore our current projects: crukcentre.manchester.ac.uk/study/research…
Happy to see our collaborative paper with Cyrus Vaziri’s lab demonstrating that RNF168 is recruited to damaged replication forks via a degenerative PIP box and its MIU1 ubiquitin binding domain is finally out in @NAR_Open : academic.oup.com/nar/advance-ar…
👏 We're delighted to have been awarded £5.9m from @CRUKresearch to develop new radiotherapy technologies and techniques over the next five years. Read more about the new funding: mcrc.manchester.ac.uk/manchester-sci… @TheChristieNHS | @OfficialUoM
We’re committing further funding for seven Radiation Research Centres of Excellence over five years to support the continued development of an internationally leading radiobiology and radiation research portfolio. Learn more about the network 👉bit.ly/3YIpOoT
Check out this beautiful study from @imPeiYee, now published in @JCellBiol!
My PhD work, funded by @wellcometrust, is out now! We showed that the #trafficking and rapid turnover of CTLA4 is #ubiquitin dependent and is linked to a complex architecture of ub chain linkages. Big thanks to @jnpruneda, Almut and Klaus-Peter for this great collab @LivUniISMIB
Another chance to join us at Birmingham. This time open also to ECRs and junior independent researchers. Genome biology is one of the priority areas (as is cancer and RNA biology). Have a look 😀. Get in touch 😀
We're delighted to announce the next cycle of recruitment for our 125th Anniversary Fellows and Chairs is now open! If you are an academic with a strong portfolio of global-leading research, we want to hear from you. Check out our vacancies and apply now: fellowsandchairs.birmingham.ac.uk/?utm_campaign=…
Lots of engaging questions, insights, networking, and candid sharing of career experiences from all the fantastic speakers at the Early Career Symposium! Thankful to @BiochemSoc for organising! #careers #ECR #BiochemEvent
It’s been a great day so far at our Early Career Symposium! We are seeing lots of engaged attendees learning, discussing and networking with expert speakers and their fellow researchers #BiochemEvent
Dr Melanie Seaton, PhD 🎓 Today was the perfect graduation day and I was so lucky to celebrate this frankly massive achievement with my wonderful family, partner and friends. I’m so so grateful to you all. On to the next adventure!! 💖🎓💫
Dear all, here is a new paper describing some of Sophie’s lovely PhD work on KU80-binding motifs (KBMs) and replication stress. It’s very interesting (he said, totally unbiased)! url.uk.m.mimecastprotect.com/s/cn1bCEx6AFDW…
Fantastic - congratulations!
It’s been a great day so far at our Early Career Symposium! We are seeing lots of engaged attendees learning, discussing and networking with expert speakers and their fellow researchers #BiochemEvent
Check out this project if you're interested in interdisciplinary research addressing how ubiquitin-like proteins regulate cell signalling in the context of the DNA damage response and cancer findaphd.com/phds/project/e…
Interested in early detection of #ovarian cancer and looking for a highly collaborative project? Look no further than the #postdoc position now open in the @C_K_Schmidt group to identify Novel Early Markers for Ovarian cancer (NEMO). Apply and more detail: jobs.manchester.ac.uk/Job/JobDetail?…
A postdoc position is available to join the group as part of an international consortium to address bottlenecks in early detection of ovarian cancer. Have a look here to find out more and apply if you're interested: jobs.manchester.ac.uk/Job/JobDetail?…
📢New #review on DUBs and ULPs in genome stability now available and open access in @Biochem_Journal #Biochemj @PPPublishing. We try to give an overview of Ub/UBL erasers in DNA damage response pathways and the mechanisms involved. Check it out! portlandpress.com/biochemj/artic…
Don't miss out! Applications for this studentship end in a week. DM me if you are interested.
Are you passionate about making a difference in the fight against blood cancer? We have a fully funded PhD studentship available to join our team and explore promising new treatment options for patients with splice factor mutations. @dwiseman78 @MCRCnews @UoM_DCS
We’re #hiring! Multiple #postdoc positions will be available in my lab to study DNA damage response signalling from June onwards. Get in touch with your CV if interested. Please RT!
A postdoc position is available to join the group as part of an international consortium to address bottlenecks in early detection of ovarian cancer. Have a look here to find out more and apply if you're interested: jobs.manchester.ac.uk/Job/JobDetail?…
Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome…