Grant Stewart

Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and Anoop Chauhan. nature.com/articles/s4146…

Great collaborative study just out in Nature Communications about RNF168 regulation by PIN1. nature.com/articles/s4146…

🧬 I'm happy to announce that our latest study, "ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping," is now available on bioRxiv! 🧬 Check it out here: biorxiv.org/content/10.110… @UCIrvine @RemiBuisson @AmbrocioSanchz @abbygreenlab 🧵🧵🧵

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦@NatureSMB⁩ #CryoEM #transcription nature.com/articles/s4159…

Delighted to announce that our paper showing the generation of iPSc from a MDS patient & how CEBPA drives disease progression is finally out in Nature Comms! A big thanks to everybody involved & the great collaborators that have made it possible! nature.com/articles/s4146…

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1

Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks dlvr.it/TLZkmH

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…

Awesome paper from @SPJacksonGroup and @FrogWalterLab about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it. nature.com/articles/s4146…

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…

Finally out! Congrats! @AndHR11 @SJimenoGonzalez @pmmargar @JoseT86910859 J. Lieberman and G. Millán Hope we contribute to the idea of supercoiling as a key regulator of genome metabolism, and not just a side-product of DNA transactions. More to come ... cell.com/cell-reports/f…

Whilst it is not related to DNA repair or replication, an interesting study I was peripherally involved in is out now @JExpMed. Dominant mutations in ITPR3 cause combined immunodeficiency in humans. Congrats to Alexandra Kreins, the lead PI of this study. rupress.org/jem/article/22…

PhD position available in the Jones lab! warwick.ac.uk/fac/cross_fac/… @MIBTP_BBSRC programme. Understanding how DNA replication and the nuclear membrane deteriorate with age. With @ZitaBalklava @AstonUniversity Application deadline 16th Jan 2025

New paper with @KokicGoran and @SvejstrupLab in Cell Press! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by @dianavandenheu2 , @MartaRodrgzMart, Paula van der Meer! cell.com/cell/fulltext/… 1/6

SRSF2 safeguards efficient transcription of DNA damage and repair genes dlvr.it/TFgt5G

Happy to share latest work from the lab! nature.com/articles/s4146…

I’m very excited to finally present something we’ve been working on for the past couple of years – a spatial proteome map of primary cilia, released in @ProteinAtlas today. Amazing teamwork led by @jn_hansen Check out our preprint doi.org/10.1101/2024.1…

POLD3 as a novel gene for non-syndromic hearing loss nature.com/articles/s4143…