Keith Caldecott
@keith_caldecott
Dear all - for those who are clinical about their genetics: a lovely collaboration with Hilde Van Esch and @guidozagnoli describing a catalytically-dead missense mutation in human TDP2 with pathology overlapping both SCAR23 and Fanconi anemia. link.springer.com/article/10.100…
Dear all, my final tweet. I can’t bear this site anymore. It’s far less toxic elsewhere in the big blue yonder (so far at least)…..
Dear all, I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on [email protected] I’m also moving (albeit somewhat clumsily and slowly!) to keithcaldecott.bsky.social, for obvious reasons….
🚨 We are looking for a new cryoEM 🔬 facility manager @SussexUni This is fantastic opportunity to work with leading researchers (like us @GDSC_Sussex) who want to observe the molecules of life and better understand human disease. newscientist.com/nsj/job/140204…
Dear all, a huge and personal thank you to Serena and Mark, our Keynote speakers at the recent GDSC birthday symposium. And another huge thank you to all of the speakers, attendees, organisers, and most of all friends and colleagues over the last 20+ years XX
Fantastic to be featured in @brightonargus today. We hope uniting cancer researchers in Sussex means that cancer patients here can benefit from, and get engaged in, the amazing research happening on their doorsteps. theargus.co.uk/news/24445605.…
Dear all, here is a new paper describing some of Sophie’s lovely PhD work on KU80-binding motifs (KBMs) and replication stress. It’s very interesting (he said, totally unbiased)! url.uk.m.mimecastprotect.com/s/cn1bCEx6AFDW…
Excited to share my latest piece I wrote for @PET_BioNews on the advancements in genome-editing therapies for cystic fibrosis and other genetic lung diseases… progress.org.uk/genome-editing…
Join the Genome Dynamics in Neuroscience and Aging , GDNA 2024, conference in Qingdao, check out the outstanding speaker line-up: gdna-cn.com/index/
Dear all, a Faculty position is available at the GDSC in Brighton, Sussex. Come join us! We’re especially excited by dynamic early career scientists looking to start, or recently started, their own lab! mailchi.mp/3e2a80a3a1e8/l…
Happy to announce the Genome Dynamics in Neuroscience and Aging GDNA2024 in Tsingtao June 9-12, 2024 Registration is now open at gdna-cn.com gdna-cn.com
Great team work - congratulations to Larissa and Amit !
Our review on DNA damage and Transcription stress is out! Check it online at Molecular Cell, thanks to the nice work with Amit Gautam and @keith_caldecott cell.com/molecular-cell…
Dear all, a new review for those interested. Think I need to find a hobby 🙄 protect-eu.mimecast.com/s/D2N_Cl7MzHK5…
Dear all, we have only few spots left for the super-😎 EMBO workshop on the "Evolution and diversity of the DNA damage response" 🔥 🔥 🔥 and few days left before the registration deadline of November 15! See you there! meetings.embo.org/event/24-dna-d…
Very excited to share our work, new on @NatureComms!!! Here, we identified TDP1 as a key factor preventing genomic instability and cell death induced by abortive TOP1 activity during gene transcription. Special thanks to @FGH_Lab !! rdcu.be/dqHQp nature.com/articles/s4146…
One week left to apply: Reader/Associate Professor in Genome Stability. Apply by 15th November for this opportunity to join the faculty of the Genome Damage and Stability Centre @GDSC_Sussex at the University of Sussex @SussexUni, Brighton. sussex.ac.uk/about/jobs/rea…
EMBO workshop on evolution and diversity of the DNA damage response is taking place in India on 19-23 February with a registration deadline of 15 November 2023: meetings.embo.org/event/24-dna-d…. A fantastic line-up of speakers, great science and a great location! See you there!
Dear all, congrats to Amit, Heather, Kamila, and Honza! Amit’s lovely work identifying a new pathway for repair of UV photodimers is now out and about…… protect-eu.mimecast.com/s/57PICZ0m3T94…
New collaborative paper on replication fork collapse at SSBs in human cells, from Almu, Sophie and colleagues in the Caldecott/Hoch/Jackson labs. An essential read if you use BrdU/CldU/IdU for your replication experiments! protect-eu.mimecast.com/s/8GZICN05NT73…
Congratulations Hana, very well deserved Dr H 💃
I am delighted and honored to have been elected an EMBO member. I thank all my fellow EMBO members for their support and trust. Congratulations to all!