Tim Kenny
@TimCKenny
@NIDDKgov K99 Postdoctoral Fellow in the @KivancBirsoy Laboratory at @RockefellerUniv by way of @IcahnMountSinai @BucknellU
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s4158…
Excited to share our perspective on solute carrier transporters - gatekeepers of metabolism sciencedirect.com/science/articl… @KivancBirsoy @YuyangLiu1996 @gadmark @TimCKenny @CellCellPress @RockefellerUniv
Choline was first described nearly 175 years ago but our understanding of this essential metabolite is still coming into focus. Excited to share our perspective @NatMetabolism! @samscharenberg @abu_remaileh @KivancBirsoy nature.com/articles/s4225…
Feel privileged to have had a front row seat to this amazing story by @EriDalla @JAguirreGhiso and colleagues focused on understanding the microenvironmental determinants of cancer cell colonization at metastatic sites with important implications for therapy. Congrats to all!
Excited to share my PhD thesis work with @JAguirreGhiso out today in @CellCellPress. Big thank you to @micpapanicolaou for bringing this across the finish line and to all our collaborators, especially @MatthewD_Park @MiriamMerad and @Casanova_Acebes! cell.com/cell/fulltext/…
I am thrilled to share that our recent study on the development of a metabolic gene function discovery platform is now online on Nature Genetics. nature.com/articles/s4158….
New work from our lab’s genomics guru @ArtemAKhan with @egamazon. Artem generated a new platform for metabolic gene discovery and identified the mitochondrial choline transporter. @RockefellerUniv @NatureGenet nature.com/articles/s4158…
(1/8) Do you eat enough choline? Have you even heard of it?? Choline is super important for the brain and must come from your diet 🐟🥚🥦 Here @Nature we show that FLVCR2 transports choline into the brain and use #cryoEM to show how! 🧠🔬 @pippomancia nature.com/articles/s4158…
Thrilled to share our recent paper published online @CellReports led by our graduate student Dimpi @Mukherjee4D 🎉 @UMassChan @UMassCancerCtr @UMassChanMCCB @UMassChanGSBS cell.com/cell-reports/f…
How does mitochondria sense and control their glutathione levels? Our new work @ScienceMagazine by a fantastic student @YuyangLiu1996 describing a redox metabolite sensing mechanism for mitochondria. @RockefellerUniv @TheMarkFdn science.org/doi/10.1126/sc…
(Thrilled to have my first Twitter Thrill) Thrilled to share my first paper published today @ScienceMagazine. How does a cell monitor metabolic homeostasis across so many subcompartments? We tried to offer a hint by looking at GSH in mitochondria. science.org/doi/10.1126/sc…
Excited to share the latest preprint from @KikaniLab! We unravel the biochemical regulation of PASK, a metabolic sensory kinase that we previously found to be necessary for establishing stem cell fate biorxiv.org/content/10.110… (Previous paper: @eLife elifesciences.org/articles/81717…)
Our review is finally out!
Online now - the Review "Targeting #SLCtransporters: small molecules as modulators and therapeutic opportunities" by @SchlessingerLab, @ColasClaire, and colleagues. #rationaldrugdesign #proteinstructureprediction #liganddiscovery cell.com/trends/biochem…
🆕🐣An egg-citing journey! Join us as we illustrate @TimCKenny @KivancBirsoy 's groundbreaking research on"Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals"🧬 Our inspiration came from one of the most choline-rich foods–eggs!🍳