Muir Lab
@Muir_Lab
(Extra)Cellular Cancer Biology @UChicagoCCB.
Launched today- the Weill Cancer Hub West -supporting transformative cancer research collaborations btw @UCSF & @Stanford. Honored to co-lead, with @longlabstanford, our team who will study the impact of diet on pancreatic cancer initiation, progression and therapy response.
Backed by a $100M gift from Joan and Sandy Weill, UCSF and @StanfordMed @StanfordCancer are launching Weill Cancer Hub West, a $200M initiative in team science to accelerate cancer research and improve care over the next decade. tiny.ucsf.edu/ppVRqt
Congrats to Dr. @PatrickJonker4 for successfully defending his @UChicagoCCB thesis yesterday!
We all know that weight loss in obesity is good- but why does it help? And why is weight regain afterward harmful? 🤔 Excited to announce our new paper is finally out in @JClinicalInvest! 🚀👇 jci.org/articles/view/…
🚨Postdoctoral position available now! 🚨We have an immediate fully funded position available in cardiac metabolism. We are looking for a highly motivated person to lead our animal model work in oxidative metabolism in heart! Pay is competitive with benefits offered. 1/2
‼️Excited to share my first preprint in the Stegmaier lab – using metabolite depletion screens in physiological culture medium and in vitro/in vivo CRISPR screens, we identify metabolism of vitamin B2 (riboflavin) as a potent dependency in acute myeloid leukemia (AML). A 🧵…
Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia biorxiv.org/content/10.110… #biorxiv_cancer
New from the Lengyel/Kenny Lab: our study in @Cancer_Cell with @labs_mann charts how borderline ovarian tumors evolve into low-grade serous ovarian cancer, using spatial proteo-transcriptomics to uncover molecular drivers & potential therapeutic targets. sciencedirect.com/science/articl…
Our faculty in the media!! Dr. Shergill is on @EverydayHealth talking about the rise in appendix cancer in GenX/millenial groups-- part of the rising rates of cancer diagnoses in young people. Learn more from Dr. Shergill at everydayhealth.com/cancer/appendi…
Excited to share our latest study from the Manning Lab. We have developed and characterized a novel mouse model lacking the five AKT phosphorylation sites on the TSC2 protein, which are critical for AKT-mediated activation of mTORC1 signaling.
Online now: AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth dlvr.it/TLBR9Q
📢New @KFW_Lab paper out! AML mitochondria remain unperturbed & phenotypically stable under diverse nutrient conditions. And rather than specific nutrients or physiological relevance, AML cell proliferation is influenced by the complete nutrient profile 👉 cancerandmetabolism.biomedcentral.com/articles/10.11…
Very cool, congratulations!
Congrats @HosungBae @Sunhee_Jung_ Johnny and co-authors for their work! @CellCellPress sciencedirect.com/science/articl…
Congrats to all #40Under40inCancer cancer researchers at UChicago! @AriRosenbergMD @ktsanov @UChicagoMed @UChicagoHemOnc @UChicagoCCB @avbcancercare
Our paper @SciImmunology shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy success in ovarian cancer. Wonderful to collaborate with @donalb5 again, Marcia Haigis & super postdoc @_Karen__S_
Scientists have uncovered how abdominal fluid called ascites in patients with high-grade serous #OvarianCancer suppresses antitumor cytotoxicity in #NaturalKiller cells. @lynchielydia @_Karen__S @donalb5 Learn more in Science #Immunology: scim.ag/43uqCz9
We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!
Assistant Professor Dr. Lillian Eichner was recognized for her excellence in research, leadership, & community impact with the Early Career Researcher of the Year Award at the @AACR Annual Meeting in Chicago! @EichnerLab is using biological findings to inform potential new…