BrentRyanLab
@BRyanLab2
Working towards understanding and treating neurodegeneration
Super proud of Libby Cowan for smashing her masters project “Mapping 3D chromatin profiles in sporadic Parkinson’s disease using iPSC-derived microglia” with top marks and being the best student a supervisor could wish for 🌟 we’ll miss you! @OxfordPDCentre @WadeMartinsLab
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @NatureComms today : nature.com/articles/s4146… @UKDRI @KingsIoPPN @ImperialMed @VIBLifeSciences
1/ 🚨 Our new paper is online in @Nature ! As its first author, I’m enthusiastic to finally share it with you all!🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 nature.com/articles/s4158… @OxfordDPAG 🧵👇
Abstracts close in 48h for the 11th ISA! isa11.org Speaker slots still available including for ECRs and PhD students, as well as poster and speaker prizes!
ABSTRACTS CLOSE 18 July! The 11th International Symposium on Autophagy 2025 📅 16–20 November 2025 | Lorne, Victoria Registration: isa11.org We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.
Excited to see finally see this one in print with all the collaborators from @_neuroproteome. All proteomic data from the publication set and the full consortia (35k samples) also now available on the ADWorkbench nature.com/articles/s4159…
Our thanks to Briana De Miranda @uab_neurology who joined us online today to give a talk to the OPDC on Initiating & persisting mechanisms of #Parkinson’s #neurodegeneration from environmental risk factors. @KavliOxford @OxfordDPAG @BRyanLab2 talks.ox.ac.uk/talks/id/06174…
I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗 nature.com/articles/s4159…
Come and work in my lab! Looking for a part time senior research tech. Stem cells & astrocytes… jobs.ac.uk/job/DNR263/sen…
I'm happy to share our new publication on formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons. #Parkinsons nature.com/articles/s4153… @LabMorten
A really wonderful day showcasing a wide range of impactful research being done by the amazing scientists in our network, and a huge pleasure to have @FionaDucotterd & @theftdbrothers involved in the day too. @ARUKscientist @ARUKThamesV #dementiaresearch #foracure
The biggest event of my year - coming to fruition! 144 delegates sharing their knowledge and dementia research findings across the Thames Valley Network. #ARUKResearchDay #foracure #researchscientist #dementiaresesrch @AlzResearchUK
A fantastic morning at the @AlzResearchUK Research Day! An emotional and inspiring talk by Jordan Adams set the tone for a day of brilliant science, including a great keynote from @FionaDucotterd on advancing medicines for neurodegenerative diseases.
Hao Lab members #ASMS2025! 6 posters, 1 oral, and 2 awards! We enjoy and embrace the great science, friendship and supportive mass spec research community at ASMS!
🚨New from our group in @CircRes We identify a FoxO1-zDHHC4-CD36 S-acylation axis driving metabolic + contractile dysfunction in the diabetic heart. Blocking this pathway reprograms FA metabolism and improves heart function. Read more: 🔗 ahajournals.org/doi/full/10.11…
Join the Hallegger Lab in Oxford. A post-doc position available to develop neuronal cell models to characterise how TDP-43 aggregation leads to its dysfunction in MND. Highly collaborative project funded by My Name'5 Doddie Foundation @MNDoddie5 Please repost and share widely!
Join us in Lorne for the 11th ISA. We have a fantastic line up of speakers at a beautiful coastal location in Australia. Hope to see you there!
Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: isa11.org Join us for five inspiring days of cutting-edge autophagy research!
🚨Come and join us! Postdoc position here at @MNDOxford @NDCNOxford, working on local subcellular dysfunction in synapses of neurons from #ALS/#FTD patients using multi-omics with @RDafinca. Check out the details below: jobs.ac.uk/job/DMV265/pos…
Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations👇🏻
CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders dlvr.it/TKRfwJ
We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". cell.com/cell-reports-m… @UKDRI @KingsIoPPN @ImperialMed
Are you an iPSC expert and interested in Alzheimer's disease? My colleague, Dr Hugo Fernandes (and the wider GSK-IMCM AD team), is looking for a new post-doc to take on this exciting project - check it out. #jobopportunity #stemcells #alzheimers jobs.ac.uk/job/DMV315/pos…
🧠Have you ever cried when your #iPSC transgene vanished after differentiation? Yeah, we’ve cried too, and built a solution. Our PiggyBac vector keeps expression stable even after differentiation! Check out our #preprint👇 🔗 biorxiv.org/content/10.110… Supported by @cziscience