Sarah Marzi
@sj_marzi
Senior Lecturer and @UKDRI Group Leader @KingsIoPPN #epigenomics #neurodegeneration 🧬🧠
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @NatureComms today : nature.com/articles/s4146… @UKDRI @KingsIoPPN @ImperialMed @VIBLifeSciences
Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: Jonas Neher, Susanne Kooistra, @MancusoRenzo. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.
How do proteins involved in the metabolism of fats in the body change your risk of developing #Alzheimer's disease? A new study from @sj_marzi and @UKDRI in @NatureComms looks at differing versions of the APOE gene and the effects on the brain. kcl.ac.uk/news/different…
Cells in key brain regions involved in Parkinson’s retain a ‘memory’ of pesticide exposure that disrupts gene expression🧬 Research by @sj_marzi & colleagues unlocks understanding of the mechanisms behind the role of pesticide exposure in Parkinson’s👉buff.ly/1F16eUB
Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻
Registration is now OPEN for the 11th Canadian Conference on Epigenetics! The annual meeting will be held November 12-15, 2025 at the @banffcentre in Banff, Alberta. You can register and find out more information at our website. event.fourwaves.com/ceehrc2025
🎙️ New podcast: Between the signals - What is motor neuron disease?🎙️ Ahead of #GlobalMNDAwarenessDay, UK DRI at King's have launched a new public podcast aimed at increasing understanding about neurodegenerative conditions Listen or watch episode 1 👉 ukdri.ac.uk/news-and-event……
What is epigenetics, and could it be important in the development of motor neuron disease / ALS? 🤔 At the UK DRI at King's, Group Leader Dr @sj_marzi lab is using cutting-edge genomic techniques to study how environmental factors over our lifetime can alter gene regulation in…
The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles. New research led by @sj_marzi offers insight into how the different versions of APOE affect…
STUDY by @sj_marzi, Kitty Murphy, et al. offers clues into how APOE isoforms differentially affect human #Microglia function in #Alzheimers, suggests how APOE2 is protective while APOE4 increases disease risk by regulating brain's immune cells @NatureComms nature.com/articles/s4146…
Dr Sarah Marzi gave an exciting presentation at #BioKorea2025, "Using epigenetics to understand how different brain cells malfunction in Importance of Epigenetics #AlzheimersDisease. @KingsIoPPN @UKDRI @KingsCollegeLon @adpdnet
Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations👇🏻
CHAS infers cell type-specific signatures in bulk brain histone acetylation studies of neurological and psychiatric disorders dlvr.it/TKRfwJ
Really nice work from the @nottalexi lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, Reuben and Alexi 👏🏻✨
A first first-author paper by Aydan Askarova with Reuben Yaa & @sj_marzi showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways 🎉📷 journals.plos.org/plosgenetics/a…… More to come from Aydan later (hopefully) this year...