Alex Bick
@AlexBickMDPhD
Genomic medicine physician-scientist @VUMCgenetics. Director, Division of Genetic Medicine @vumc_medicine
Thank you @David_Ouyang for a fantastic Vanderbilt Medicine Grand Rounds talk today!
Thanks @AlexBickMDPhD Dan Roden Bryan Harris @piperbelow for inviting me to @vumc_medicine. Great to see old and new friends alike! Precision AI phenotyping and @VUMCgenetics is an amazing match for discovery science! 🚀 And 🙏 to allow me to kick off the new…
A new preprint led by @AlexBickMDPhD, @madduri, and @yash_pershad, with co-authors including @LabAgarwal and RRP’s @EricsonKatrin, uses a closed-loop #AI system to identify and validate therapeutic targets for RUNX1-FPD. One of these targets, mTOR, supports earlier findings by…
New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with @madduri & @RUNX1Research supported by @cziscience. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗biorxiv.org/content/10.110… 🧵by @yash_persh👇
Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…
Delighted to collaborate on this study led by @jieliu09 @KellyLBolton describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy nature.com/articles/s4158… @NatureGenet
Very excited to share our paper investigating the evolution of therapy-related CH in myeloma pts treated w/ or w/o LEN. Can we predict the risk for second blood cancer in myeloma pts? Grateful for the collaboration with @UCCancerCenter myeloma program. nature.com/articles/s4137…
New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with @madduri & @RUNX1Research supported by @cziscience. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗biorxiv.org/content/10.110… 🧵by @yash_persh👇
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
Amazing to see the broadening reach of HSC transplant-based therapies!!! 🩸 -> 🧠 science.org/doi/10.1126/sc…
Whoa! Big increase in the DP2 New Innovator budget. Great news!
This is a great funding opportunity for early career scientists with great ideas that advance science and health. Please apply!
Congratulations @tigerstatdoc @SumeetKhetarpal @WalterWChen1 @PeggyPHsu and all of the other 2025 @BWFUND CAMS awardees! bwfund.org/news/bwf-annou…
How reliable is plasma cell-free DNA for detection of clonal hematopoiesis? Would love to chat about it tonight at the #EHA25 poster session! Poster PS-2315 :)
Thanks to Millburn High School for inviting me back for the Science Research Symposium. As an early member of the program, it was an honor to support and encourage these young scientists.
💡IMO one of the best use of AI Scientist is to reanalyze data to find new insights. Introducing #CellVoyager: AI Compbio Agent that makes new discoveries by autonomously analyzing papers/data, which we then validate🚀 New findings on aging, Covid, scRNAseq etc. Open source!
New paper in @TheLancet eClinicalMedicine with James Brogan & @AshKishtagari @VUMChealth We found that cytopenia is a key step from #CHIP ➡️ myeloid neoplasm (MN). Cytopenia-free survival = a new CHIP trial endpoint? doi.org/10.1016/j.ecli…
I am thrilled to share our new publication in @eClinicalMedicine co-led with a superb @VUMChealth IM resident James Brogan: "Incident cytopenia and risk of subsequent myeloid neoplasm in age-related clonal hematopoiesis" sciencedirect.com/science/articl… We analyzed 805,249 participants…
🤯 Wow, $REGN bought 23andMe for $256 million. cnn.com/2025/05/19/bus…
Thank you so much to @patrickhu and all the other amazing folks, including @NancyGenetics, @AlexBickMDPhD, @ZinkelLab, @egamazon, from the @VUMC_MedPSTP + @VUMCDiscoveries I had the privilege to interact with as the Harrison Society Visiting Professor!
Many thanks to Harrison Society Visiting Professor @bloodgenes for his AMAZING @VUMCDiscoveries Medicine Grand Rounds presentation on genotype-phenotype correlations in human hematopoiesis (and sage advice to our young physician-scientists over lunch)
(1/n) New preprint from @claricehongky Fan Fang @VarshiniRam23 in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…
Excited to share my first preprint from @hansen_lab! It's got genomics, AI, and biology - all wrapped up in a great paper. Also very grateful to my amazing collaborator, Fan, for all his hard work. Please check it out and let me know what you think! tinyurl.com/bdfvtd6f
🤯Wow, Kári Stefánsson stepped down from deCODE - end of an era. ruv.is/english/2025-0…
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! @tigerstatdoc's talk to @broadinstitute @BroadMPG : A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFSuk… We are incredibly lucky to have her…
Honored to be selected as a 2025 @VanderbiltU Chancellor Faculty Fellow! news.vanderbilt.edu/2025/05/01/11-…
