Anna-Lena Neehus

Very happy to share our review @bloodgenes published today in JHI. We discuss how rare and common genetic variants influence early B cell development and can underlie susceptibility to infectious diseases, autoimmunity and leukemia. 🔬🧬

1/ Join us on 24 Sept 2025 at the @InstitutImagine in Paris for the Novo Nordisk Prize Symposium: Inborn Errors of Immunity. Registration is free at: my.weezevent.com/novo-nordisk-p…

Alioua, Rosain @JRosain @hopital_necker and colleagues describe seven intronic pathogenic variants underlying inborn errors of immunity. hubs.la/Q03xKk7M0 #InbornErrorsOfImmunity

Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by @michaelpoeschla, along with @SashaGusevPosts, @mitchiela, @SharonSavageMD, @hemanth_tummala, and others, published as an advanced online paper in @jclinicalinvest today:…

1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)

Scientists have discovered that LY9 deficiency in a subset of T helper cells impairs #interferonγ responses and underlies susceptibility to #tuberculosis in humans. @RockefellerUniv @casanova_lab @MasatoOgishi Learn more in Science #Immunology: scim.ag/4mC4fQP

Thousands of GWAS hits—but how do we link them to biology? 🚨New from Alkes Price group: J-PEP integrates pleiotropy and epigenomic data to reveal shared disease mechanisms across diseases surl.li/gtzlnr #genomics #Statistics @HarvardChanSPH

1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @JExpMed uncovers the underlying immunological mechanism   rupress.org/jem/article/22…

The first JHI articles are online! Poli et al present the 2024 update of the @iuis_online classification of #InbornErrorsOfImmunity (hubs.la/Q03hwdHg0) & Bousfiha et al provide an accompanying phenotypic classification to assist clinical diagnoses (hubs.la/Q03hvT0f0)

I am incredibly fortunate to be able to work with this amazing group @HHMINEWS, @BostonChildrens, @DanaFarber, @harvardmed, @broadinstitute!!! 🙏🩸🧬

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…

Gene therapy is transforming how we treat genetic disorders, but what if mutations in more than 30 genes can cause similar symptoms? Now published in @CellStemCell (cell.com/cell-stem-cell…), we report the development of a universal gene therapy for Diamond Blackfan anemia. 1/n

1/9 As part of my Ph.D. @UTSWMedCenter in @MishraLab, I’m excited to share our Science Advances findings on how mtDNA mutations impact melanoma metastasis. science.org/doi/10.1126/sc…

We are looking for a motivated research assistant to work at the intersection of human genetics, immunology and molecular biology at Vanderbilt University Medical Center in Nashville. Interested? Please, apply using the link below. vumc.wd1.myworkdayjobs.com/vumccareers/jo…

Leaving this years #ESID2024 meeting where i had the chance to present my previous and current work and got to meet many fantastic scientist and friends! Thank you @ESIDsociety for this exciting meeting full of inspiration and I am looking forward to the next one!

Congrats to my friend @Jonathan_Bohlen for another amazing story published! 🎉 Very happy to have had the chance to work with you on this project! Check out the complete thread on human CBL deficiency 👇

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

🔬 Looking for a PhD research project in Paris, France? The International PhD PPU-IMAGINE program might be just for you! Find out more: form.jotform.com/241074680515353