Jonathan Bohlen (@Jonathan_Bohlen)

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Jonathan Bohlen@Jonathan_Bohlen · Nov 15

I have decided to withdraw myself to posting research papers only on this website. Unfortunately, it has become neither enjoyable nor productive to be here. If you want, come and hang out, for example on bluesky: bsky.app/profile/jonath…

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Stephanie_Boisson-Dupuis@BoissonDupuis · Jun 2

1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)

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Fahd Al Qureshah, PhD | فهد آل قريشه@alqurefa · Dec 16

1/ I am excited to share our new paper from @casanova_lab published today in @JExpMed about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem.20…).

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Jonathan Bohlen@Jonathan_Bohlen · Dec 5

We reported recessive DBR1 deficiency underlying brainstem viral encephalitis in humans in 2018 (sciencedirect.com/science/articl…) then 2024 (rupress.org/jem/article/22…). The molecular mechanism remained mysterious. Here it comes. Congrats to Daxing and team for the great findings!!!

JJournal of Experimental Medicine@JExpMed · Dec 5

Shuo Ru, Daxing Gao et al. show that the accumulation of RNA lariats in human DBR1-deficient cells impairs #StressGranule assembly–mediated PKR activation, and thereby cell-intrinsic antiviral immunity. hubs.la/Q02-zrTc0 @casanova_lab @ShenYingZhang1 #Immunodeficiency

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Jonathan Bohlen@Jonathan_Bohlen · Nov 28

Landmark paper from my colleague and friend Masato @casanova_lab ! A must read!!

MMasato OGISHI@MasatoOgishi · Nov 26

1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstr…

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Human Immunology News@humanimmunenews · Oct 25

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated #monocyte activation, reports @Jonathan_Bohlen and colleagues. 💬 More in @jclinicalinvest: bit.ly/3NEfh84

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Journal of Clinical Investigation@jclinicalinvest · Oct 24

Why do some patients with a CBL genotype develop autoinflammatory disease?jci.org/articles/view/… @Jonathan_Bohlen @casanova_lab and team report on chronic monocyte activation through the ERK pathway as a major contributor in patients with CBL LOF variants.

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Jonathan Bohlen@Jonathan_Bohlen · Oct 21

Wow, what an amazing experience this year's @ESIDsociety meeting was! A community driven by scientific curiosity and the motivation to help patients. It was a huge pleasure to present my work in front of this audience!

Jonathan_Bohlen's tweet image. Wow, what an amazing experience this year's @ESIDsociety meeting was! A community driven by scientific curiosity and the motivation to help patients. It was a huge pleasure to present my work in front of this audience!

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Jonathan Bohlen@Jonathan_Bohlen · Oct 17

A beautiful investigation into how germline heterozygous CBL variants lead to autoinflammation when accompanied by somatic loss of heterozygosity

JJonathan Bohlen@Jonathan_Bohlen · Oct 15

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

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Jonathan Bohlen@Jonathan_Bohlen · Oct 16

Germline + somatic CBL mutations in leukocytes result in autoinflammation. Great work led by @Jonathan_Bohlen !

JJonathan Bohlen@Jonathan_Bohlen · Oct 15

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

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Jonathan Bohlen@Jonathan_Bohlen · Oct 15

Congrats to my friend @Jonathan_Bohlen for another amazing story published! 🎉 Very happy to have had the chance to work with you on this project! Check out the complete thread on human CBL deficiency 👇

JJonathan Bohlen@Jonathan_Bohlen · Oct 15

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

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Jonathan Bohlen@Jonathan_Bohlen · Oct 15

Excellent thread by @Jonathan_Bohlen about germline + somatic deficiency of CBL in leukocytes resulting in autoinflammation via dysregulation of monocytes !

JJonathan Bohlen@Jonathan_Bohlen · Oct 15

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

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Waggoner Lab@LabWaggoner · Oct 15

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation @jclinicalinvest @casanova_lab @BustamanteJaci1 @Jonathan_Bohlen jci.org/articles/view/…

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