Xuebing Wu
@wu_xuebing
Assistant Professor @Columbia University | Ribosome, translation, RNA, CRISPR, genomics | alum @MIT @WhiteheadInst @Tsinghua_Uni | #hiringNow
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJBLQb
Check out our paper, now extensively revised and published in @MolecularCell! This has been a real tour de force led by @stephsansbury and @YSereb and we are very excited about the findings and future potential of this approach cell.com/molecular-cell…
Our updated preprint on the mechanism behind the 1st & only human disease linked to tissue-specific ribosome: fatal heart failure caused by RPL3L mutations. Very proud of this work led by the talented and fearless Michael Murphy @MMurphyCUNY—check out his thread for more details!
Excited to share our new preprint from the @wu_xuebing lab: biorxiv.org/content/10.110… In it, we identify a gain-of-toxicity mechanism in RPL3L-linked neonatal dilated cardiomyopathy (DCM), challenging the idea that recessive diseases are primarily caused by loss-of-function.
Part 1 of the exciting work from Michael Murphy @MMurphyCUNY in the lab. Great experience with @biorxivpreprint - submitted 2pm yesterday and already online 6am today. This is what science publishing should look like biorxiv.org/content/10.110…
As alumni I'm sad to see a mit professor publicly shaming chinese students in a top conference without citing credible sources. The more serious question is: did she make it up? I dont see any sensible person would make such a confession. @MIT @NeurIPSConf
Mitigating racial bias from LLMs is a lot easier than removing it from humans! Can’t believe this happened at the best AI conference @NeurIPSConf We have ethical reviews for authors, but missed it for invited speakers? 😡
We are hiring a technician to help with CRISPR screens. Prior experience with CRISPR screens and large-scale cell culture is preferred but not required. Please feel free to share: jobrxiv.org/job/columbia-u…
Hey RNA folks, a question about the discovery of the genetic code: Nirenberg and Matthaei famously showed that poly-U encodes poly-phenylalanine using a poly-U synthetic RNA in E. coli lysate. But there is no start codon in poly-U. How did translation start on poly-U RNA?
Thrilled to share our review article, 'Mechanisms Suppressing Noncoding Translation,' co-authored w/ @JordanKesner1. Grateful to @TrendsCellBio editors Bryan Harada (@structural_biol) and Ilaria Carnevale (@i_carnevale) for their invitation and support! authors.elsevier.com/a/1jzmb3QxxSux…
We are thrilled to welcome Dr. Markus Covert from @Stanford on May 1st, hosted by Dr. @MoAlQuraishi. The title of the seminar is "The E. coli Whole-Cell Modeling Project: from Simulation to Discovery" and will be from 3-4pm in ICRC 816.
great opportunity for those interested in translating RNA regulation into therapeutics!
As some of you might know, I have helped cofound this startup with colleagues @WendyKChung and Francesco Lotti focusing on RNA-based therapeutics. We are up and running at Alexandria LaunchLabs on the Columbia Medical Center campus. Now we are hiring #RNA enthusiasts to join!…
Super excited to start our new adventure in neurodegeneration with the support from @MINDPrize, our 2nd grant from @PershingSqFdn. Congrats to other awardees especially my @ColumbiaPS colleague and fellow RNA enthusiast Hachung @hchung03!
We are thrilled to announce the recipients of the 2024 MIND Prize! Seven researchers across the USA who are paving the way to a deeper and transformative understanding of the brain: pershingsquarefoundation.org/2024/03/26/pre…