Michael Murphy

U.K. approves world’s first CRISPR-based medicine, giving greenlight to therapy for sickle cell, thalassemia statnews.com/2023/11/16/u-k… via @statnews

Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells go.nature.com/3EsAAoe

The #gnomAD team is proud to announce the release of gnomAD v4! The v4 dataset includes 730,947 exomes & 76,215 genomes, which is ~5x larger than the v2 & v3 releases combined, & includes nearly 120K indivs of non-European genetic ancestry broad.io/gnomad_v4 #ASHG23 (1/11)

Very excited to share our work on cancer nanomedicine now out in @ScienceMagazine. This was a really fun and collaborative project co-led by @natalie_boehnke and supported by an amazing group of scientists @kochinstitute @broadinstitute @DFBC_PedCare science.org/doi/10.1126/sc…

Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules dlvr.it/SVLdYL

Are you thinking about performing 40S ribosome footprinting (TCP-seq) or even selective 40S/80S ribosome footprinting (Sel-TCP-seq)? It can seem daunting and too complex 🧐 For this reason we have now published a comprehensive summary of the method(s):nature.com/articles/s4159…

SHAME ON @illumina. All my labs 150+ iseq and novaseq runs deleted off @BaseSpace. Why? I exceeded 1 TB and didnt check my lab's gmail. There is apparently nothing they can do now. All my lab's data is gone ... I have some backups ...

"Thirteen dubious ways to detect conserved RNA structure" W Gao, A Yang, E Rivas. rivaslab.org/publications/R… Is it a conserved RNA structure, or not? ...or can we even tell?

I pretty regularly share the super plots paper by @samjlord and @MullinsLab with new core users, lab members, and collaborators. It has one of my favorite figures of all time. ncbi.nlm.nih.gov/pmc/articles/P…

VASA-seq sequences total RNA in single cells, revealing non-coding expression and splicing patterns go.nature.com/3u2ONDS

fascinating new paper in Cell shows that many insect genomes harbor HUNDREDS of genes derived from bacteria and acquired at some point through horizontal gene transfer among these, a gene from Listeria essential for male butterfly mating behavior cell.com/cell/fulltext/…