GreiffLab 💻🔬💊
@victorgreiff
Computational and Systems Immunology Lab @UniOslo and @Imprintlabs. Immune receptor profiling | Machine learning | Antibody engineering
Extremely pleased to share our new work in collaboration with the @Bruskolab lab where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in sorted pancreatic lymph nodes (pLN) & spleen cohorts. 🧬🧵 #T1D #Immunology #TCR 1/9
New preprint: Allostery is a widespread cause of loss-of-function variant pathogenicity by the great @liao_xiaotian biorxiv.org/content/10.110….
congrats to @amyxlu on the publication of her work "Tokenized and continuous embedding compressions of protein sequence and structure" in @Patterns_CP ! thanks to all co-authors! @wilson1yan @KevinKaichuang @GligorijevicV @kchonyc @pabbeel @RichBonneauNYC Link below 👇
We're looking for talented people to join our team! Adaptyv is growing super fast and we need more hands on deck to manage our lab, BD and ops! Please send me a DM if you have recommendations for who we should hire
We're hiring! Come work with us to democratize protein engineering. At Adaptyv, our high-throughput cloud lab enables protein designers to experimentally validate their proteins with the click of a button. We're building advanced molecular biology workflows, assay automation…
Very cool! You can now predict structures with Boltz directly within ChimeraX! 👏🔥
The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @plantsci jobs.cam.ac.uk/job/51488/
🚨New work from our lab with important clinical implications. Thanks to our collaborators in @TheHPAP. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv biorxiv.org/content/10.110…
Excited to share a preprint reporting on the cellular and molecular immune profile of human T1D from @DiabetesnPOD. Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development biorxiv.org/content/10.110…
📣Major thanks to @xiaofei_lin at @GENbio for this lovely piece on IMPRINT! It was a pleasure for our founders — @BeckBrachman, @victorgreiff, and Raymond Alvarez — to speak about our mission and research. The piece also covers our pioneering status as New York’s first Focused…
Excited to co-found and help lead @IMPRINTlabs—a focused effort to decode the immune system’s memory through cutting-edge computation and experimentation. Grateful to be on this journey with an exceptional team.
🧵 Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases. imprint.org/press-release-… With teams in Europe and North America, we are…
We have available a 3-year postdoc position in Bioinformatics in Oslo focusing on the adaptive immune response in rheumatoid arthritis. Please see details here lds.easycruit.com/vacancy/349055…
Online now: Somatic hypermutation unlocks antibody specificities beyond the primary repertoire dlvr.it/TKcvbY
Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlocking high-throughput functional TCR screening from single-cell data. 🧵@kochinstitute @MEBirnbaum @MITChemE @MIT biorxiv.org/content/10.110…
🚨Looking for a job in immunology and biotech research? IMPRINT is #hiring! Join us to help revolutionize how we decode the body’s immune memory, uncover the causes of chronic diseases, and drive breakthroughs in autoimmunity and neuropsychiatric research. IMPRINT is seeking…
We couldn’t be more excited to announce our partnership with Arc Institute and 10x Genomics to accelerate development of the Arc Virtual Cell Atlas. Read more: insideprecisionmedicine.com/topics/informa… #NGS #SingleCell #VirtualCell #AIBIO
Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: hecklab.com/advanced-prote…
🚀 Excited to release a major update to the Boltz-1 model: Boltz-1x! Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training, and more! 🔥🧵
Thanks to the efforts of all the amazing people in the protein design community we managed to write up a cool paper after our protein design competitions at Adaptyv. One of the key takeaways was: to design better proteins we need better models and those models need better data.
Introducing BenchBB and the community paper of the Protein Design Competition 🎉 We wrote a community paper about our Protein Design Competition, teaming up with your favourite protein designers from both rounds. Excited to announce that this is now on Biorxiv 🙌
Hello world! Have you heard of the AIRR Knowledge Commons yet? The AKC is being established as an integrated resource immune receptors, repertoires, antigen specificity and germline gene information. Want to know more? Check our new website: airr-knowledge.org
Please come visit our shared super booth at #AAI!
🚨Science Booth Alert🧪📈 Join us at our #AAI Immunology Super Booth (#535 & #537) with @CEDAR_epitopes, @hipcProject & @AIRR_Knowledge to understand how complex immune data can be used to create unique insights for #Immunology research #AAI2025 immunology2025.aai.org