Dmitry Velmeshev

In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14

Congratulations Li, another impressive achievement with interesting implications and a resource for our field. Well done!

The next installment of the ‘Mediterranean’ Cortical Development meeting will take place in Sicily next year! Hoping to see you all there.

Our paper on cell type-specific changes in dup15q syndrome during development and in the adult human brain is out in NatureComms: nature.com/articles/s4146…. Thanks to the co-first author Yonatan Perez, @Kriegsteinlab and all authors. Special thanks to donors and @AutismBrainNet!

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…

My lab is hiring 2 postdocs on a NIH-funded grant characterizing molecular & cellular changes in the human brain across menopausal transition. Other neuroepigenomics projects are also available. We plan to hire a wet lab scientist & a bioinformatician. Please RT! More info 👇

In @CellReports, @ArantxaCebrian, Arturo Alvarez-Buylla, PhD, and their colleagues show that B2 cells are an important population of secondary neural stem cells that sustain neurogenesis in adult mice: doi.org/10.1016/j.celr… @UCSFstemcell

Despite the trying times, thrilled to share our @NatureProtocols piece on massively parallel in vivo Perturb-seq: nature.com/articles/s4159…

1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders. cell.com/cell/abstract/…

🧬 A Quantum leap in single cell analysis! Read our blog introducing Quantum Barcoding: - 2M cells in just 1.5 days - 75% less hands-on time - Costs as low as $0.01/cell - Up to 9,216 samples per run Learn more ⬇️ hubs.la/Q02Y_Kws0

I am delighted to inform everyone that the next tri-annual Cortical Development meeting to be held in Sicily is now online and available for registration: corticaldevelopment.wordpress.com Looking forward to hearing from and seeing everyone in this beautiful and historic site!

I am very proud to present Dr. Beika Zhu's work: biorxiv.org/cgi/content/sh…

Come see us at #SfN2024 in Chicago! The Duke Neurobiology Graduate Training Program booth will be open from 📅Saturday to Tuesday, ⏰12-2 PM. Meet with students, faculty, and learn about joining our world-class research community @DukeNeuro!

Are you attending #SfN24 and interested in brain development? Please join us for the cortical development nano symposium on October 8 at 8:00 AM!

Please RT: We are hiring! Apply to join the exciting research going on @DukeCellBiology! jobs.sciencecareers.org/job/662805/fac…

Debra Silver, PhD, has been honored with the 2024 Javits Award from @NIH for her groundbreaking work on intellectual disability and autism. Her research on radial glia cells continues to illuminate the complexities of neurological disorders. @TheSilverLab medschool.duke.edu/news/debra-sil…

We are delighted to be a part of several exciting collaborative projects and are looking for a senior scientist to lead organoid generation and analysis for these projects, with room to develop independent projects as well. Please apply or share! recruit.apo.ucla.edu/JPF09796

Please hold the date for the next CORTICAL DEVELOPMENT MEETING in Giardini Naxos, Sicily, Italy - May 25-28, 2025 @corticaldev2022 @Kriegsteinlab @GordFishell @FloraVaccarino

Interested in using stem cells to create more mature human cortical neurons for studying intact living brain circuits? Excited to share our @NatureProtocols @RevahLab, Felicity Gore, @KaganovskyNeuro, @XiaoyuChenxy, @KarlDeisseroth, @Sergiu_P_Pasca nature.com/articles/s4159…

Epigenome editing is transforming biological sciences and medicine. We're grateful for the opportunity to publish this review of the field in @NatureBiotech. Check it out here: rdcu.be/dPjsJ