Alexi Nott 🏳️‍🌈

Nice to see this review out with @IRHoltman! | Genetic insights into immune mechanisms of Alzheimer’s and Parkinson’s disease | frontiersin.org/articles/10.33…

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬 New paper out in @NatureComms today : nature.com/articles/s4146… @UKDRI @KingsIoPPN @ImperialMed @VIBLifeSciences

📢 Big news! #Neuroepi25 has just released the final programme! 👉 Check it out now on the conference website ✅ And don't forget to register - this is a conference you won’t want to miss! Click here for more information: bit.ly/3SWzHfa

It's a pleasure to welcome a new Group Leader to the UK DRI! 🙌 🎉 🥳 Prof @PareshMalhotra joins our Care Research & Tech Centre @ImperialBrains to harness new opportunities & data generated by trials to transform the way that dementia treatments are evaluated at the level of…

Thrilled to join the @UKDRI & @TheBHF as a Group Leader in the Vascular Dementia Centre, and proud to bring the UKDRI to Oxford for the first time! 🧠🎉 Excited to build collaborations & advance research on the BBB in brain diseases #SalmanLab @OxfordDPAG @KavliOxford

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @UKDRI @ucl - pls help circulate among networks who’d be of interest, thank you!

Trying to get cell type specific insights from bulk brain epigenetic studies? Check out our new method CHAS for cell type deconvolution in brain studies of histone acetylation. Reanalysis of bulk data from >300 samples revealed novel cell type specific epigenetic associations👇🏻

Really nice work from the @nottalexi lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, Reuben and Alexi 👏🏻✨

A first first-author paper by Aydan Askarova with Reuben Yaa & @sj_marzi showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways 🎉📷 journals.plos.org/plosgenetics/a…… More to come from Aydan later (hopefully) this year...

We are so happy to share our latest paper "CHAS infers cell type-specific signatures in bulk brain acetylation studies of neurological and psychiatric disorders". cell.com/cell-reports-m… @UKDRI @KingsIoPPN @ImperialMed

Wonderful evening with Shane Liddelow following his visit to @ImperialBrains @UKDRI 🧠

@nottalexi we are looking forward to your presentation at #Neuroepi25 in Malta.🌞 Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025! Find out more: bit.ly/42ls1an #FusionNeuro

We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @NatureComms today: nature.com/articles/s4146…

The Dept. of Brain Sciences at Imperial (@ImperialBrains) is recruiting a new Head of Department (link below). Keen to have someone great take the role, and come and work with us! Please pass onto anyone that might be interested

Thank you to @UKDRI Group Leader @nottalexi for joining us today & for his great talk on ‘The Epigenome of brain cell types and associations with disease’ @KavliOxford @OxfordDPAG @SophieFarrow2

Exciting new role for a Computational Genomics Research Associate in the lab of @sj_marzi at the UK DRI at King's! Lead projects exploring the epigenome and transcriptome of brain cells in neurodegenerative diseases 🧠 🗓️Deadline: 08 March Full info👉 shorturl.at/fk7jS

The advert is officially live and you can apply online here: tinyurl.com/yd5bsvfb

Last day @UKDRI @ImperialBrains before starting my maternity leave 🍼 I will only briefly come back before heading to Turin for a new adventure @MSCActions 🇮🇹Millions thanks to this bunch of people who supported me through these last 4 intense years! 💙🙏

Are you looking for a fully funded #PhD studentship? Join our Dr Nurun Fancy for a studentship for 3.5 year project investigating the role of LRRK2 in cellular senescence in Parkinson’s Disease. Find out more👇 imperial.ac.uk/brain-sciences…

📢 Our lab is looking for a bioinformatics postdoc. We have lots of exciting projects to work on, including single cell data, microglia xenotransplantations and nanopore long reads splicing analysis. Look out for the official advert next week and get in touch in the meantime 🧬🧠

🚨 Check out our latest contribution where we delve into the dementia-related snRNA-seq data and spotlight the signature changes in brain #endothelialcells and #pericytes! Very proud of the effort led by Dr. Michael Sewell and Nela Fialova @fialovanel. alz-journals.onlinelibrary.wiley.com/doi/full/10.10…