oftenindoubt
@oftenindoubt
Thinking out loud about mitochondrial dysfunction, metabolic psych, and related topics. Sometimes wrong, often in doubt. Not medical advice.
Speculative, but retatrutide—a triple agonist that binds to GLP-1, GIP, and glucagon receptors—may end up being a strong treatment for this. All three receptors increase cAMP and trigger a cascade that activates GlyP.
A newly discovered "sugar switch" in the brain might unlock new ways to prevent Alzheimer’s, scientists reveal. This is fascinating - let's take a look... 🧵
The reason you don’t need a randomized controlled trial for parachutes is because “what goes up must come down” is a lot simpler to interpret than this:
Most mental illnesses don’t “run in families.” A Danish study of 3M people shows most cases arise without family history, underscoring the complex and unpredictable nature of mental health. neurosciencenews.com/mental-health-…
Why do we sleep? What happens in our cells that make us feel the need to go to bed? New study in flies showing that as energy flows with more energy resistance (éR) in our mitochondria--producing "reductive stress"-- the pressure to sleep increases Manipulating mitochondrial…
'water is transparent only within a very narrow band of the electromagnetic spectrum, so living organisms evolved sensitivity to that band, and that's what we now call "visible light". ' (found via HN)
WHAT MAKES A MATURE SCIENCE. "There are exceptions to every rule" is a common phrase in biology. But what if we could reorganize biology such that this wasn't the case? In a new article, @mold_time argue we should try, even if “biology” is too broad of a field for this to work.
Peering into mitochondria - gorgeous life patterns! The parallel infolding are "cristae" where respiration and energy transformation happen The purpose of breathing is to bring oxygen to your cristae
“Free fatty acids cause insulin resistance in all major insulin target organs and have emerged as a major link between obesity, the development of the metabolic syndrome, and atherosclerotic vascular disease. Free fatty acids also produce low-grade inflammation in skeletal…
Any substance, to qualify as a physiological link between obesity and insulin resistance, should meet at least the following three criteria: 1) The substance should be elevated in the blood of obese people. 2) Raising its blood level (within physiologic limits) should increase…
At its root, any neurodegenerative/neuropsychiatric disease (like Alzheimer's) is characterized by imbalances in GABA and glutamate, neuroinflammation, and mitochondrial dysfunction. This is the biophysics - the brain responds to electric, magnetic, and photonic signals…
Did you know? At 103, some brains still defy Alzheimer’s. A new study found that centenarians with low amyloid-beta, a type of misfolded protein that increases in the brain with age, buildup scored higher in executive function—and even a few with high levels stayed sharp thanks…
Seeing this mitochondrial reconstruction for the first time with @MitoLoveLab was one of the most exciting sight ever! It changed my life. What do you see? The story behind cristae alignment here: scientificamerican.com/article/why-mi…
Collagen is a story in peptides and organotherapy The peptide sequence GHK is found repeated in the alpha 2 chain of type 1 collagen It makes sense since GHK copper peptide up-regulates repair of collagen As collagen is broken down and damaged, GHK is released, which signals…
How is it possible in the recent Nature paper from Glen Jeffery and Bob Fosbury that visual improvement could occur even though there was no ocular exposure to the light? Answer: mitochondria talk to each other across organs: This is mind blowing. pmc.ncbi.nlm.nih.gov/articles/PMC10…
As someone with the E200K PRNP gene mutation, this excites me the most about retatrutide. GLP-1s improve cognitive function through several key mechanisms: •Better brain energy metabolism (enhanced insulin sensitivity = sharper thinking) •Reduced neuroinflammation (the…
There's a huge frontier of science to be done by people who are not afraid to risk their reputation on the rigorous study of woo
That animals seemingly anticipate events should humble us more. Changes in groundwater chemistry, electromagnetic fields and sound waves make animals restless, distressed and even relocate In the West it is seen as ‘woo’ to contemplate that energy/weather humans don’t…
We cover basic knowledge about key metabolic pathways, including how energy is transformed in mitochondria using oxygen, and "anaerobically" through glycolysis Ultimately, every electron we eat must meet with oxygen, but the brain and some other organs can transform quite a bit…
This paper led by psychiatrist Dost Ongur reviews what we know and don't know about brain bioenergetics and how the brain works
Bone building cells (osteoblasts) have their own internal circadian clock. When your circadian rhythm is disrupted due to irregular sleep patterns. Osteoblasts produce higher levels of a protein called RANKL. This protein activates osteoclasts, cells that break down bone, leading…
on this day in 2021, @mold_time tweeted:
The study of obesity is the study of mysteries. slimemoldtimemold.com/2021/07/07/a-c…