Neville Sanjana
@nevillesanjana
🚨📰TWEETORIAL time📰🚨 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagenesis of the MYC TAD (~3 Mb) in 6 different human cancer cell lines nature.com/articles/s4146…
Great video from the Ramon y Cajal of brain mapping in the genetics era: Ed Lein. Amazing facts on the human brain map from the video: At least 3,000 cell types and much of that diversity is not in neocortex. Beautiful!
What makes the human brain unique? Most diseases of the human brain are only seen in humans. By understanding what makes the human brain different, we can understand more about these unique diseases. #studyBRAIN
Beautiful deep dive from Sri on what it means to predict cell behavior (/virtual cell /foundation model). Great Sunday read with references to Brenner, Ptashne, Arkin and many others.
I'm also experimenting with SS; I've found X and BS getting pretty tedious these days, and SS to be a bit of a breath of fresh air. That said, this piece is likely way too long, and it's dangerous for me to have a longer form medium. srikosuri.substack.com/p/the-elusive-…
Amazing work from former lab member @joshim5 on AI-enabled, one-shot protein design. Go Josh & @chaidiscovery ! 🚀
We prompt Chai-2 with 50 targets, test the designs in the lab, and observe a >15% hit rate. In just 2 weeks, we generate molecules, and synthesize + characterize them in the lab, without any iterative optimization or high-throughput lab screening.
The micropipette—that ubiquitous tool found in laboratories around the world—was invented by a 32-year-old German postdoc in 1957 after a particularly productive two-day tantrum. That first device, made by Heinrich Schnitger, had “all the essential features of the modern…
“This is reality; it’s not science fiction. We’re actually doing it. I’ve had patients of mine in the trial receive this one-and-done treatment, and it’s going to change the face of cholesterol management going forward.” sciencefocus.com/news/new-chole…
Fantastic interview. In the NYT interview, @rcbregman also mentions abolitionist Thomas Clarkson (who had a fascinating life: en.wikipedia.org/wiki/Thomas_Cl…) and who was also in the news this week about the discovery of an original Magna Carta: hls.harvard.edu/today/harvard-…
One toddler. Four wake-ups. Zero REM sleep. That’s how I prepped for being interviewed by David Marchese for The New York Times. 🧵
What wonderful news — great to see more and more benefits of gene editing therapies 🚀
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… @NEJM…
"Here’s a contrarian take. It’s better to get AI engineers excited to work on the audacious goals of advancing human health vs. working on chatbots, customer support agents, and agent infrastructure" - @pdhsu Agree — 100%! (and this is a great interview)
This was a fun one — new Endpoints Slack interview with @pdhsu: endpts.com/endpoints-slac…
And also some experiments from our lab @nygenome and @nyuniversity (led by #ChristinaCaragine) — good luck to the @framonauts on their return to Earth in the next day or two!
In an awe-inspiring moment from the @framonauts’ Fram2 mission, our #Science Cubes MELITE and Space-THAL were captured floating freely in the cupola with the Earth’s polar regions in the background. These scientific studies, led by Malta’s biotech company @Spaceomix, are the…
Amazing addition to @nygenome — very lucky to have a pioneer in functional genomics joining us. Welcome Bing! 🚀🚀🚀
We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the NYGC. Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment. For more on Dr. Ren: bit.ly/3DJXtah
During graduate school, I read many textbooks but the clearest and best one by far was @stevenstrogatz 's Nonlinear Dynamics and Chaos. Important to see that — like with everything in life — it's just about working at it, getting better and not giving up!
It takes me dozens of drafts to write anything. Here, for example, are three stages (out of 60+) of the opening of INFINITE POWERS. A rough idea, followed by an early attempt at sentences, followed by the final version.
Our lab generated 4 new lines of Cas12a transgenic mice and demonstrated utility in immune engineering, tumor modeling, and genetic disease treatment. Around to share w the field & community! @YaleMed @YaleWest @YaleGenetics @YaleData Also @LabWinslow nature.com/articles/s4155…
Beautiful new work on gene therapy for Dravet (SCNA1A)!
New hope for families battling Dravet Syndrome. Scientists have developed a new gene replacement therapy that could improve treatments for a rare and life-altering form of epilepsy. 🧵